UniProt Accession

 ACTB_RAT; P60711; P02570; P70514; P99021; Q11211; Q64316 

Genbank Protein ID

 V01217; BC063166 

Genbank Nucleotide ID

 CAA24528.1; AAH63166.1 

Protein Name

 Actin, cytoplasmic 1 

Protein Synonyms/Alias

 Beta-actin; Actin, cytoplasmic 1, N-terminally processed 

Gene Name

 Actb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
50	VMVGMGQKDSYVGDE	acetylation	[1]
50	VMVGMGQKDSYVGDE	ubiquitination	[2]
61	VGDEAQSKRGILTLK	acetylation	[1]
61	VGDEAQSKRGILTLK	ubiquitination	[2]
68	KRGILTLKYPIEHGI	acetylation	[1]
113	TEAPLNPKANREKMT	acetylation	[1]
113	TEAPLNPKANREKMT	ubiquitination	[2]
291	KCDVDIRKDLYANTV	ubiquitination	[2]
315	GIADRMQKEITALAP	acetylation	[1]
315	GIADRMQKEITALAP	ubiquitination	[2]
326	ALAPSTMKIKIIAPP	acetylation	[1]
326	ALAPSTMKIKIIAPP	ubiquitination	[2]
328	APSTMKIKIIAPPER	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylaspartate; in Actin, cytoplasmic
 MOD_RES 44 44 Methionine sulfoxide (By similarity).
 MOD_RES 73 73 Tele-methylhistidine (By similarity).
 MOD_RES 218 218 Nitrated tyrosine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Methylation; Nitration; Nucleotide-binding; Oxidation; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:RGD.
 GO:0030863; C:cortical cytoskeleton; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0070688; C:MLL5-L complex; IEA:Compara.
 GO:0035267; C:NuA4 histone acetyltransferase complex; IEA:Compara.
 GO:0014069; C:postsynaptic density; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0030529; C:ribonucleoprotein complex; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0007409; P:axonogenesis; IDA:RGD. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 

PRINTS

 PR00190; ACTIN.