| Tag | Content |
|---|
| CPLM ID | CPLM-003504 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nucleoside triphosphate pyrophosphohydrolase |
Protein Synonyms/Alias | NTP-PPase |
Gene Name | mazG |
Gene Synonyms/Alias | b2781; JW2752 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 119 | LARWEQIKTEERAQK | acetylation | [1] | | 211 | LARHLGTKAEIALQK | acetylation | [1] | | 222 | ALQKANEKFERRFRE | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA. |
Sequence Annotation | NP_BIND 168 172 ATP 1.
NP_BIND 189 192 ATP 1.
NP_BIND 222 226 ATP 2.
METAL 172 172 Magnesium.
METAL 175 175 Magnesium.
METAL 193 193 Magnesium.
METAL 196 196 Magnesium.
BINDING 175 175 ATP 1.
BINDING 196 196 ATP 1.
BINDING 253 253 ATP 2. |
Keyword | 3D-structure; ATP-binding; Complete proteome; Hydrolase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 263 AA |
Protein Sequence | MNQIDRLLTI MQRLRDPENG CPWDKEQTFA TIAPYTLEET YEVLDAIARE DFDDLRGELG 60
DLLFQVVFYA QMAQEEGRFD FNDICAAISD KLERRHPHVF ADSSAENSSE VLARWEQIKT 120
EERAQKAQHS ALDDIPRSLP ALMRAQKIQK RCANVGFDWT TLGPVVDKVY EEIDEVMYEA 180
RQAVVDQAKL EEEMGDLLFA TVNLARHLGT KAEIALQKAN EKFERRFREV ERIVAARGLE 240
MTGVDLETME EVWQQVKRQE IDL 263 |
Gene Ontology | GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0047693; F:ATP diphosphatase activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IDA:EcoCyc. GO:0009267; P:cellular response to starvation; IMP:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |