| Tag | Content |
|---|
| CPLM ID | CPLM-014637 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase delta |
Protein Synonyms/Alias | Protein-tyrosine phosphatase delta; R-PTP-delta |
Gene Name | Ptprd |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1308 | KSSLPNSKEVPSHHP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | |
Sequence Annotation | DOMAIN 24 114 Ig-like C2-type 1.
DOMAIN 126 224 Ig-like C2-type 2.
DOMAIN 236 318 Ig-like C2-type 3.
DOMAIN 323 410 Fibronectin type-III 1.
DOMAIN 417 511 Fibronectin type-III 2.
DOMAIN 516 604 Fibronectin type-III 3.
DOMAIN 609 706 Fibronectin type-III 4.
DOMAIN 711 819 Fibronectin type-III 5.
DOMAIN 820 913 Fibronectin type-III 6.
DOMAIN 918 1013 Fibronectin type-III 7.
DOMAIN 1021 1103 Fibronectin type-III 8.
DOMAIN 1357 1612 Tyrosine-protein phosphatase 1.
DOMAIN 1644 1903 Tyrosine-protein phosphatase 2.
REGION 180 189 Sufficient for interaction with IL1RAPL1.
REGION 227 230 Contributes to IL1RAPL1 binding.
REGION 1553 1559 Substrate binding (By similarity).
ACT_SITE 1553 1553 Phosphocysteine intermediate (By
ACT_SITE 1844 1844 Phosphocysteine intermediate (By
BINDING 1521 1521 Substrate (By similarity).
BINDING 1597 1597 Substrate (By similarity).
CARBOHYD 254 254 N-linked (GlcNAc...) (Potential).
CARBOHYD 299 299 N-linked (GlcNAc...) (Potential).
CARBOHYD 724 724 N-linked (GlcNAc...) (Potential).
CARBOHYD 832 832 N-linked (GlcNAc...) (Potential).
DISULFID 45 98 Potential.
DISULFID 147 207 Potential.
DISULFID 257 302 Potential. |
Keyword | Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Immunoglobulin domain; Membrane; Protein phosphatase; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1912 AA |
Protein Sequence | MVPVARPLSL LLTFFLCACA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK 60
GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ 120
IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS 180
ESIGGTPIRG ALQIEQSEES DQGKYECVAT NSAGTRYSAP ANLYVRELRE VRRVPPRFSI 240
PPTNHEIMPG GSVNITCVAV GSPMPYVKWM LGAEDLTPED DMPIGRNVLE LNDVRQSANY 300
TCVAMSTLGV IEAIAQITVK ALPKPPGTPV VTESTATSIT LTWDSGNPEP VSYYIIQHKP 360
KNSEEPYKEI DGIATTRYSV AGLSPYSDYE FRVVAVNNIG RGPASEPVLT QTSEQAPSSA 420
PRDVQARMLS STTILVQWKE PEEPNGQIQG YRVYYTMDPT QHVNNWMKHN VADSQITTIG 480
NLVPQKTYSV KVLAFTSIGD GPLSSDIQVI TQTGVPGQPL NFKAEPESET SILLSWTPPR 540
SDTIASYELV YRDGDQGEEQ RITIEPGTSY RLQGLKPNSL YYFRLSARSP QGLGASTAEI 600
SARTMQSKPS APPQDISCTS PSSTSILVSW QPPPVEKQNG IITEYSLKYA AVDGEDFKPH 660
EILGIPSDTT KYLLEQLEKW TEYRITVTAH TDVGPGPESL SVLIRTDEDV PSGPPRKVEV 720
EAVNATAVKV SWRSPVPNKQ HGQIRGYQVH YVKMENGEPK GQPMLKDVML ADAQWEFDDT 780
TEHDMIISGL QPETSYSLTV TAYTTKGDGA RSKPKLVSTT GAVPGKPRLV INHTQMNTAL 840
IQWHPPVDTF GPLQGYRLKF GRKDMEPLTT LEFSEKEDHF TATDIHKGAS YVFRLSARNK 900
VGFGEEMVKE ISVPEEIPTG FPQNLHSEGT TSTSVQLSWQ PPVLAERNGV ITKYTLLYRD 960
INVPLLPMEH LIVPADTSMT LTGLKSDTTY DVKVRAHTSK GPGPYSPSVQ FRTLPVDQVF 1020
AKNFHVKAVM KTSVLLSWEI PENYNSAMPF KILYDDGKMV EEVDGRATQK LIVNLKPEKS 1080
YSFVLTNRGN SAGGLQHRVT AKTAPDVLRT KPAFIGKTNL DGMITVQLPD VPANENIKGY 1140
YIIIVPLKKS RGKFIKPWES PDEMELDELL KEISRKRRSI RYGREVELKP YIAAHFDVLP 1200
TEFTLGDDKH YGGFTNKQLQ SGQEYVFFVL AVMDHAESKM YATSPYSDPV VSMDLDPQPI 1260
TDEEEGLIWV VGPVLAVVFI ICIVIAILLY KRKRAESESR KSSLPNSKEV PSHHPTDPVE 1320
LRRLNFQTPG MASHPPIPIL ELADHIERLK ANDNLKFSQE YESIDPGQQF TWEHSNLEVN 1380
KPKNRYANVI AYDHSRVLLS AIEGIPGSDY VNANYIDGYR KQNAYIATQG SLPETFGDFW 1440
RMIWEQRSAT VVMMTKLEER SRVKCDQYWP SRGTETHGLV QVTLLDTVEL ATYCVRTFAL 1500
YKNGSSEKRE VRQFQFTAWP DHGVPEHPTP FLAFLRRVKT CNPPDAGPMV VHCSAGVGRT 1560
GCFIVIDAML ERIKHEKTVD IYGHVTLMRA QRNYMVQTED QYIFIHDALL EAVTCGNTEV 1620
PARNLYAYIQ KLTQIETGEN VTGMELEFKR LASSKAHTSR FISANLPCNK FKNRLVNIMP 1680
YESTRVCLQP IRGVEGSDYI NASFLDGYRQ QKAYIATQGP LAETTEDFWR MLWEHNSTIV 1740
VMLTKLREMG REKCHQYWPA ERSARYQYFV VDPMAEYNMP QYILREFKVT DARDGQSRTV 1800
RQFQFTDWPE QGVPKSGEGF IDFIGQVHKT KEQFGQDGPI SVHCSAGVGR TGVFITLSIV 1860
LERMRYEGVV DIFQTVKMLR TQRPAMVQTE DQYQFCYRAA LEYLGSFDHY AT 1912 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. GO:0007157; P:heterophilic cell-cell adhesion; IDA:BHF-UCL. GO:0030182; P:neuron differentiation; IDA:BHF-UCL. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. GO:0050775; P:positive regulation of dendrite morphogenesis; IDA:BHF-UCL. GO:0097105; P:presynaptic membrane assembly; IDA:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |