| Tag | Content |
|---|
| CPLM ID | CPLM-014052 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | LDLR chaperone MESD |
Protein Synonyms/Alias | Mesoderm development candidate 2; Mesoderm development protein |
Gene Name | Mesdc2 |
Gene Synonyms/Alias | Mesd |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 91 | FSKLDPGKPESILKM | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction (By similarity). |
Sequence Annotation | REGION 1 155 Chaperone domain (By similarity).
REGION 156 195 Escort domain (By similarity).
MOTIF 221 224 Prevents secretion from ER.
CARBOHYD 192 192 N-linked (GlcNAc...) (Potential). |
Keyword | Chaperone; Complete proteome; Endoplasmic reticulum; Glycoprotein; Reference proteome; Signal; Wnt signaling pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 224 AA |
Protein Sequence | MAASSWLRAV LLFLCASDLL LLSPPEAYAT DTPGEAITPP RKKKDIRDYN DADMARLLEQ 60
WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK KGKTLMMFVT ISGNPTEKET 120
EEITSLWQGS LFNANYDVQR FIVGSDRAIF MLRDGSYAWE IKDFLVNQDR CAEVTLEGQM 180
YPGKGGGSKE KNKTKPEKGK KKEGDPKPRA SKEDNRAGSR REDL 224 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:Compara. GO:0006457; P:protein folding; ISS:UniProtKB. GO:0034394; P:protein localization to cell surface; IEA:Compara. GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
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PRINTS | |