CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022605
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cyclin-T1 
Protein Synonyms/Alias
 CycT1; Cyclin-T 
Gene Name
 Ccnt1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
491KVHSAGDKHNSIEDSacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). 
Sequence Annotation
 MOTIF 253 270 Nuclear localization signal (Potential).
 MOD_RES 117 117 Phosphoserine (By similarity).
 MOD_RES 390 390 N6-acetyllysine (By similarity).
 MOD_RES 494 494 Phosphoserine (By similarity).
 MOD_RES 498 498 Phosphoserine (By similarity).  
Keyword
 Acetylation; Cell cycle; Cell division; Coiled coil; Complete proteome; Cyclin; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 724 AA 
Protein Sequence
MEGERKNNNK RWYFTREQLE NSPSRRFGVD SDKELSYRQQ AANLLQDMGQ RLNVSQLTIN 60
TAIVYMHRFY MIQSFTQFHR YSMAPAALFL AAKVEEQPKK LEHVIKVAHT CLHPQESLPD 120
TRSEAYLQQV QDLVILESII LQTLGFELTI DHPHTHVVKC TQLVRASKDL AQTSYFMATN 180
SLHLTTFSLQ YTPPVVACVC IHLACKWSNW EIPVSTDGKH WWEYVDATVT LELLDELTHE 240
FLQILEKTPS RLKRIRNWRA YQAAMKTKPD DRGADENTSE QTILNMISQT SSDTTIAGLM 300
SMSTASTSAV PSLPSSEESS SSLTSVDMLQ GERWLSSQPP FKLEAAQGHR TSESLALIGV 360
DHSLQQDGSS AFGSQKQASK SVPSAKVSLK EYRAKHAEEL AAQKRQLENM EANVKSQYAY 420
AAQNLLSHDS HSSVILKMPI ESSENPERPF LDKADKSALK MRLPVASGDK AVSSKPEEIK 480
MRIKVHSAGD KHNSIEDSVT KSREHKEKQR THPSNHHHHH NHHSHRHSHL QLPAGPVSKR 540
PSDPKHSSQT STLAHKTYSL SSTLSSSSST RKRGPPEETG AAVFDHPAKI AKSTKSSLNF 600
PFPPLPTMTQ LPGHSSDTSG LPFSQPSCKT RVPHMKLDKG PPGANGHNAT QSIDYQDTVN 660
MLHSLLSAQG VQPTQAPAFE FVHSYGEYMN PRAGAISSRS GTTDKPRPPP LPSEPPPPLP 720
PLPK 724 
Gene Ontology
 GO:0008024; C:positive transcription elongation factor complex b; ISS:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0017069; F:snRNA binding; IDA:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0006468; P:protein phosphorylation; ISO:MGI.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR013763; Cyclin-like.
 IPR015429; Cyclin_C/H/T/L.
 IPR006671; Cyclin_N. 
Pfam
 PF00134; Cyclin_N 
SMART
 SM00385; CYCLIN 
PROSITE
 PS00292; CYCLINS 
PRINTS