UniProt Accession

 CHSP1_HUMAN; Q9Y2V2; B2R4C3; D3DUF5; Q2YDX5; Q9BQ53 

Genbank Protein ID

 AF115345; AK311777; CH471112; CH471112; CH471112; CH471112; BC003366; BC108283 

Genbank Nucleotide ID

 AAD25021.1; BAG34720.1; EAW85196.1; EAW85197.1; EAW85198.1; EAW85199.1; AAH03366.1; AAI08284.1 

Protein Name

 Calcium-regulated heat stable protein 1 

Protein Synonyms/Alias

 Calcium-regulated heat-stable protein of 24 kDa; CRHSP-24 

Gene Name

 CARHSP1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	ASQGPVYKGVCKCFC	ubiquitination	[1, 2, 3]
68	PVYKGVCKCFCRSKG	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro). 

Sequence Annotation

 DOMAIN 62 129 CSD.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 30 30 Phosphoserine.
 MOD_RES 32 32 Phosphoserine.
 MOD_RES 41 41 Phosphoserine.
 MOD_RES 45 45 Phosphothreonine.
 MOD_RES 52 52 Phosphoserine.
 MOD_RES 146 146 Phosphoserine.
 MOD_RES 147 147 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0043186; C:P granule; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003730; F:mRNA 3'-UTR binding; IDA:UniProtKB.
 GO:0019902; F:phosphatase binding; NAS:UniProtKB.
 GO:0035556; P:intracellular signal transduction; TAS:ProtInc.
 GO:0043488; P:regulation of mRNA stability; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 

Interpro

 IPR019844; Cold-shock_CS.
 IPR011129; Cold_shock_prot.
 IPR002059; CSP_DNA-bd.
 IPR012340; NA-bd_OB-fold. 

Pfam

 PF00313; CSD 

SMART

 SM00357; CSP 

PROSITE

 PS00352; COLD_SHOCK 

PRINTS