UniProt Accession

 RBM4B_HUMAN; Q9BQ04; B3KT83 

Genbank Protein ID

 AK095158; CH471076; BC003503; BC004951 

Genbank Nucleotide ID

 BAG52995.1; EAW74558.1; AAH03503.1; AAH04951.1 

Protein Name

 RNA-binding protein 4B 

Protein Synonyms/Alias

 RNA-binding motif protein 30; RNA-binding motif protein 4B; RNA-binding protein 30 

Gene Name

 RBM4B 

Gene Synonyms/Alias

 RBM30 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
3	*****MVKLFIGNLP	ubiquitination	[1]
27	SLFEQYGKVLECDII	ubiquitination	[1]
35	VLECDIIKNYGFVHI	ubiquitination	[1]
45	GFVHIEDKTAAEDAI	ubiquitination	[1]
59	IRNLHHYKLHGVNIN	ubiquitination	[1]
73	NVEASKNKSKASTKL	ubiquitination	[1]
97	TNQELRAKFEEYGPV	ubiquitination	[1]
111	VIECDIVKDYAFVHM	ubiquitination	[1]
139	DNTEFQGKRMHVQLS	ubiquitination	[1]
173	GKEGHWSKECPVDRT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity). 

Sequence Annotation

 DOMAIN 2 72 RRM 1.
 DOMAIN 78 148 RRM 2.
 ZN_FING 160 177 CCHC-type.
 REGION 196 359 Interaction with TNPO3 (By similarity).  

Keyword

 3D-structure; Activator; Complete proteome; Direct protein sequencing; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Polymorphism; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 359 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
 GO:0043153; P:entrainment of circadian clock by photoperiod; ISS:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0006417; P:regulation of translation; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR001878; Znf_CCHC. 

Pfam

 PF00076; RRM_1
 PF00098; zf-CCHC 

SMART

 SM00360; RRM
 SM00343; ZnF_C2HC 

PROSITE

 PS50102; RRM
 PS50158; ZF_CCHC 

PRINTS