CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-037040
UniProt Accession
E7ESP4_HUMAN
;
E7ESP4
Genbank Protein ID
AC008966
Genbank Nucleotide ID
Protein Name
Integrin alpha-2
Protein Synonyms/Alias
Gene Name
ITGA2
Gene Synonyms/Alias
Created Date
July 27, 2013
Organism
Homo sapiens (Human)
NCBI Taxa ID
9606
Lysine Modification
Position
Peptide
Type
References
821
FIVSNQN
K
RLTFSVT
ubiquitination
[1]
Reference
[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [
PMID: 21906983
]
Functional Description
Sequence Annotation
Keyword
Cell adhesion; Complete proteome; Integrin; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
942 AA
Protein Sequence
MGPERTGAAP LPLLLVLALS QGILNCCLAY NVGLPEAKIF SGPSSEQFGY AVQQFINPKG 60
NWLLVGSPWS GFPENRMGDV YKCPVDLSTA TCEKLNLQTS TSIPNVTEMK TNMSLGLILT 120
RNMGTGGFLT CGPLWAQQCG NQYYTTGVCS DISPDFQLSA SFSPATQPCP SLIDVVVVCD 180
ESNSIYPWDA VKNFLEKFVQ GLDIGPTKTQ VGLIQYANNP RVVFNLNTYK TKEEMIVATS 240
QTSQYGGDLT NTFGAIQYAR KYAYSAASGG RRSATKVMVV VTDGESHDGS MLKAVIDQCN 300
HDNILRFGIA VLGYLNRNAL DTKNLIKEIK AIASIPTERY FFNVSDEAAL LEKAGTLGEQ 360
IFSIEGTVQG GDNFQMEMSQ VGFSADYSSQ NDILMLGAVG AFGWSGTIVQ KTSHGHLIFP 420
KQAFDQILQD RNHSSYLGYS VAAISTGEST HFVAGAPRAN YTGQIVLYSV NENGNITVIQ 480
AHRGDQIGSY FGSVLCSVDV DKDTITDVLL VGAPMYMSDL KKEEGRVYLF TIKEGILGQH 540
QFLEGPEGIE NTRFGSAIAA LSDINMDGFN DVIVGSPLEN QNSGAVYIYN GHQGTIRTKY 600
SQKILGSDGA FRSHLQYFGR SLDGYGDLNG DSITDVSIGA FGQVVQLWSQ SIADVAIEAS 660
FTPEKITLVN KNAQIILKLC FSAKFRPTKQ NNQVAIVYNI TLDADGFSSR VTSRGLFKEN 720
NERCLQKNMV VNQAQSCPEH IIYIQEPSDV VNSLDLRVDI SLENPGTSPA LEAYSETAKV 780
FSIPFHKDCG EDGLCISDLV LDVRQIPAAQ EQPFIVSNQN KRLTFSVTLK NKRESAYNTG 840
IVVDFSENLF FASFSLPVDG TEVTCQVAAS QKSVACDVGY PALKREQQVT FTINFDFNLQ 900
NLQNQASLSF QALSESQEEN KADNLVNLKI PLLYDAEIHL TR 942
Gene Ontology
GO:0045178
; C:basal part of cell; IEA:Compara.
GO:0009897
; C:external side of plasma membrane; IEA:Compara.
GO:0008305
; C:integrin complex; IEA:InterPro.
GO:0007155
; P:cell adhesion; IEA:UniProtKB-KW.
GO:0007229
; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
Interpro
IPR013517
; FG-GAP.
IPR013519
; Int_alpha_beta-p.
IPR000413
; Integrin_alpha.
IPR013649
; Integrin_alpha-2.
IPR002035
; VWF_A.
Pfam
PF01839
; FG-GAP
PF08441
; Integrin_alpha2
PF00092
; VWA
SMART
SM00191
; Int_alpha
SM00327
; VWA
PROSITE
PS51470
; FG_GAP
PS50234
; VWFA
PRINTS
PR01185
; INTEGRINA.