CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019010
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 tRNA modification GTPase GTPBP3, mitochondrial 
Protein Synonyms/Alias
 GTP-binding protein 3; Mitochondrial GTP-binding protein 1 
Gene Name
 GTPBP3 
Gene Synonyms/Alias
 MTGP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
152RRAFANGKLNLTEVEubiquitination[1]
272LVNLLSRKPVSIVSPubiquitination[1, 2]
452LGHYKQSKDLALAAEubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs (Probable). 
Sequence Annotation
 NP_BIND 256 263 GTP (Potential).
 NP_BIND 303 307 GTP (Potential).
 NP_BIND 374 377 GTP (Potential).  
Keyword
 Alternative splicing; Complete proteome; GTP-binding; Mitochondrion; Nucleotide-binding; Polymorphism; Reference proteome; Transit peptide; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 492 AA 
Protein Sequence
MWRGLWTLAA QAARGPRRLC TRRSSGAPAP GSGATIFALS SGQGRCGIAV IRTSGPASGH 60
ALRILTAPRD LPLARHASLR LLSDPRSGEP LDRALVLWFP GPQSFTGEDC VEFHVHGGPA 120
VVSGVLQALG SVPGLRPAEA GEFTRRAFAN GKLNLTEVEG LADLIHAETE AQRRQALRQL 180
DGELGHLCRG WAETLTKALA HVEAYIDFGE DDNLEEGVLE QADIEVRALQ VALGAHLRDA 240
RRGQRLRSGV HVVVTGPPNA GKSSLVNLLS RKPVSIVSPE PGTTRDVLET PVDLAGFPVL 300
LSDTAGLREG VGPVEQEGVR RARERLEQAD LILAMLDASD LASPSSCNFL ATVVASVGAQ 360
SPSDSSQRLL LVLNKSDLLS PEGPGPGPDL PPHLLLSCLT GEGLDGLLEA LRKELAAVCG 420
DPSTDPPLLT RARHQHHLQG CLDALGHYKQ SKDLALAAEA LRVARGHLTR LTGGGGTEEI 480
LDIIFQDFCV GK 492 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:LIFEdb.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0006400; P:tRNA modification; IEA:InterPro. 
Interpro
 IPR018948; GTP-bd_TrmE_N.
 IPR006073; GTP_binding_domain.
 IPR004520; GTPase_MnmE.
 IPR025867; GTPase_MnmE_C_dom.
 IPR027368; MnmE_dom2.
 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR027266; TrmE/GcvT_dom1. 
Pfam
 PF12631; GTPase_Cys_C
 PF01926; MMR_HSR1
 PF10396; TrmE_N 
SMART
  
PROSITE
  
PRINTS