CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013418
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mitochondrial glutamate carrier 2 
Protein Synonyms/Alias
 GC-2; Glutamate/H(+) symporter 2; Solute carrier family 25 member 18 
Gene Name
 Slc25a18 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
84LTLVTPEKAIKLAANacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity). 
Sequence Annotation
 REPEAT 11 97 Solcar 1.
 REPEAT 105 215 Solcar 2.
 REPEAT 224 313 Solcar 3.  
Keyword
 Complete proteome; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 320 AA 
Protein Sequence
MIACRMSSQD LSITAKLING GIAGLVGVTC VFPIDLAKTR LQNQQGKDVY KGMTDCLVKT 60
ARAEGFLGMY RGAAVNLTLV TPEKAIKLAA NDFLRQLLMQ DGTQRNLKME MLAGCGAGIC 120
QVVITCPMEM LKIQLQDAGR LAVCQQASAS ATPTSRPYST GSTSTHRRPS ATLIAWELLR 180
TQGLSGLYRG LGATLLRDIP FSIIYFPLFA NLNQLGVSEL TGKASFTHSF VAGCAAGSVS 240
AVAVTPLDVL KTRIQTLKKG LGEDTYRGVT DCARKLWTQE GAAAFMKGAG CRALVIAPLF 300
GIAQGVYFIG IGERILKCFE 320 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW. 
Interpro
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS
 PR00926; MITOCARRIER.