CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009090
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/calcium exchanger 3 
Protein Synonyms/Alias
 Na(+)/Ca(2+)-exchange protein 3 
Gene Name
 SLC8A3 
Gene Synonyms/Alias
 NCX3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
349YALSHQQKSRAFYRIubiquitination[1]
370TGAGNILKKHAAEQAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity). 
Sequence Annotation
 REPEAT 140 180 Alpha-1.
 DOMAIN 386 485 Calx-beta 1.
 DOMAIN 519 619 Calx-beta 2.
 REPEAT 796 832 Alpha-2.
 REGION 253 272 Calmodulin-binding (By similarity).
 CARBOHYD 45 45 N-linked (GlcNAc...) (Potential).
 CARBOHYD 823 823 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Antiport; Calcium; Calcium transport; Calmodulin-binding; Complete proteome; Glycoprotein; Ion transport; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 927 AA 
Protein Sequence
MAWLRLQPLT SAFLHFGLVT FVLFLNGLRA EAGGSGDVPS TGQNNESCSG SSDCKEGVIL 60
PIWYPENPSL GDKIARVIVY FVALIYMFLG VSIIADRFMA SIEVITSQER EVTIKKPNGE 120
TSTTTIRVWN ETVSNLTLMA LGSSAPEILL SLIEVCGHGF IAGDLGPSTI VGSAAFNMFI 180
IIGICVYVIP DGETRKIKHL RVFFITAAWS IFAYIWLYMI LAVFSPGVVQ VWEGLLTLFF 240
FPVCVLLAWV ADKRLLFYKY MHKKYRTDKH RGIIIETEGD HPKGIEMDGK MMNSHFLDGN 300
LVPLEGKEVD ESRREMIRIL KDLKQKHPEK DLDQLVEMAN YYALSHQQKS RAFYRIQATR 360
MMTGAGNILK KHAAEQAKKA SSMSEVHTDE PEDFISKVFF DPCSYQCLEN CGAVLLTVVR 420
KGGDMSKTMY VDYKTEDGSA NAGADYEFTE GTVVLKPGET QKEFSVGIID DDIFEEDEHF 480
FVRLSNVRIE EEQPEEGMPP AIFNSLPLPR AVLASPCVAT VTILDDDHAG IFTFECDTIH 540
VSESIGVMEV KVLRTSGARG TVIVPFRTVE GTAKGGGEDF EDTYGELEFK NDETVKTIRV 600
KIVDEEEYER QENFFIALGE PKWMERGISA LLLSPDVTDR KLTMEEEEAK RIAEMGKPVL 660
GEHPKLEVII EESYEFKTTV DKLIKKTNLA LVVGTHSWRD QFMEAITVSA AGDEDEDESG 720
EERLPSCFDY VMHFLTVFWK VLFACVPPTE YCHGWACFAV SILIIGMLTA IIGDLASHFG 780
CTIGLKDSVT AVVFVAFGTS VPDTFASKAA ALQDVYADAS IGNVTGSNAV NVFLGIGLAW 840
SVAAIYWALQ GQEFHVSAGT LAFSVTLFTI FAFVCISVLL YRRRPHLGGE LGGPRGCKLA 900
TTWLFVSLWL LYILFATLEA YCYIKGF 927 
Gene Ontology
 GO:0043197; C:dendritic spine; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0043025; C:neuronal cell body; IEA:Compara.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0042383; C:sarcolemma; IEA:Compara.
 GO:0005432; F:calcium:sodium antiporter activity; IEA:Compara.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0060402; P:calcium ion transport into cytosol; IEA:Compara.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0071320; P:cellular response to cAMP; IEA:Compara.
 GO:0006811; P:ion transport; TAS:Reactome.
 GO:0021537; P:telencephalon development; IEA:Compara.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 
Interpro
 IPR003644; Calx_beta.
 IPR004836; Na_Ca_Ex.
 IPR004837; NaCa_Exmemb. 
Pfam
 PF03160; Calx-beta
 PF01699; Na_Ca_ex 
SMART
 SM00237; Calx_beta 
PROSITE
  
PRINTS
 PR01259; NACAEXCHNGR.