UniProt Accession

 RK_HUMAN; Q15835; Q53X14 

Genbank Protein ID

 U63973; L77503; L77502; L77496; L77497; L77498; L77499; L77500; L77501; AC187648; AK289912 

Genbank Nucleotide ID

 AAB05929.1; AAG50439.1; AAT00534.2; AAT00534.2; AAT00534.2; AAT00534.2; AAT00534.2; AAT00534.2; AAT00534.2; BAF82601.1 

Protein Name

 Rhodopsin kinase 

Protein Synonyms/Alias

 RK; G protein-coupled receptor kinase 1 

Gene Name

 GRK1 

Gene Synonyms/Alias

 RHOK 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
418	EPVKYPDKFSQASKD	acetylation	[1]
424	DKFSQASKDFCEALL	acetylation	[1]
437	LLEKDPEKRLGFRDE	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. 

Sequence Annotation

 DOMAIN 58 175 RGS.
 DOMAIN 190 455 Protein kinase.
 DOMAIN 456 521 AGC-kinase C-terminal.
 NP_BIND 196 204 ATP (By similarity).
 REGION 1 189 N-terminal.
 REGION 456 563 C-terminal.
 ACT_SITE 317 317 Proton acceptor (By similarity).
 BINDING 219 219 ATP (By similarity).
 MOD_RES 5 5 Phosphoserine (By similarity).
 MOD_RES 8 8 Phosphothreonine (By similarity).
 MOD_RES 21 21 Phosphoserine; by PKA and autocatalysis.
 MOD_RES 491 491 Phosphoserine; by autocatalysis (By
 MOD_RES 492 492 Phosphothreonine; by autocatalysis (By
 MOD_RES 560 560 Cysteine methyl ester (By similarity).
 LIPID 560 560 S-farnesyl cysteine (By similarity).  

Keyword

 ATP-binding; Complete proteome; Congenital stationary night blindness; Disease mutation; Kinase; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Polymorphism; Prenylation; Reference proteome; Sensory transduction; Serine/threonine-protein kinase; Transferase; Vision. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 563 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004703; F:G-protein coupled receptor kinase activity; IEA:InterPro.
 GO:0050254; F:rhodopsin kinase activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0008594; P:photoreceptor cell morphogenesis; IEA:Compara.
 GO:0042327; P:positive regulation of phosphorylation; IEA:Compara.
 GO:0060060; P:post-embryonic retina morphogenesis in camera-type eye; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IMP:UniProtKB.
 GO:0022400; P:regulation of rhodopsin mediated signaling pathway; IDA:UniProtKB.
 GO:0016056; P:rhodopsin mediated signaling pathway; TAS:ProtInc.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR000961; AGC-kinase_C.
 IPR000239; GPCR_kinase.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR000342; Regulat_G_prot_signal.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase
 PF00615; RGS 

SMART

 SM00315; RGS
 SM00133; S_TK_X
 SM00220; S_TKc 

PROSITE

 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50132; RGS 

PRINTS

 PR00717; GPCRKINASE.