| Tag | Content |
|---|
| CPLM ID | CPLM-018706 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Metastasis-associated protein MTA3 |
Protein Synonyms/Alias | |
Gene Name | Mta3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 32 | RRIEELNKTASGNVE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (By similarity). |
Sequence Annotation | DOMAIN 1 147 BAH.
DOMAIN 148 258 ELM2.
DOMAIN 265 317 SANT.
ZN_FING 377 404 GATA-type; atypical.
MOD_RES 452 452 Phosphothreonine (By similarity).
MOD_RES 454 454 Phosphoserine (By similarity).
MOD_RES 516 516 Phosphoserine (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 591 AA |
Protein Sequence | MAANMYRVGD YVYFENSSSN PYLIRRIEEL NKTASGNVEA KVVCFYRRRD ISNTLIMLAD 60
KHAKETEEES ETPVEADLTE KQKHQLKHRE LFLSRQYESL PATHIRGKCS VALLNETESV 120
LSYLDKEDTF FYSLVYDPSV KTLLADKGEI RVGPKYQADI PDMLPEDSDE REQSKLEVKV 180
WDPNSPLTDR QIDQFLVVAR AVGTFARALD CSSSVRQPSL HMSAAAASRD ITLFHAMDTL 240
YRHGYDLSSA ISVLVPLGGP VLCRDEMEEW SASEACLFEE ALEKYGKDFN DIRQDFLPWK 300
SLTSIIEYYY MWKTTDRYVQ QKRLKAAEAE SKLKQVYIPT YKPNPNQISS SNGKAGTVNG 360
AVGTQFQPQS ALLGRACESC YATQSHQWYS WGPPNMQCRL CATCWLYWKK YGGLKMPTQS 420
DEEKSPSPTA EDPRARSHMS RQALQGMPVR NTGSPKSAVK TRQAFFLRTT YFTKIARQVC 480
KSTLRLRQAA RRPFVAINYA AIRAEYADRH AELSGSPLKS RSTRKPLSCI IGYLEIHPAK 540
KPNVIRSPPS LQTPATKRML AAPNHTSLSI LGKRNYSHHN GLDGPERWLS R 591 |
Gene Ontology | GO:0008278; C:cohesin complex; IDA:MGI. GO:0005737; C:cytoplasm; IDA:MGI. GO:0016581; C:NuRD complex; IDA:MGI. GO:0003682; F:chromatin binding; IEA:InterPro. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0008284; P:positive regulation of cell proliferation; IMP:MGI. GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |