Tag | Content |
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CPLM ID | CPLM-005056 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase |
Protein Synonyms/Alias | Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase |
Gene Name | murE |
Gene Synonyms/Alias | b0085; JW0083 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
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252 | VGRRWLAKLPDAVAV | acetylation | [1] | 367 | HTPDALEKALQAARL | acetylation | [1] | 439 | MLDAGHAKVMEGRAE | acetylation | [1, 2] |
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Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli. Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z. J Proteome Res. 2013 Feb 1;12(2):844-51. [ PMID: 23294111] |
Functional Description | Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine. |
Sequence Annotation | NP_BIND 116 122 ATP (Potential). REGION 44 46 UDP-MurNAc-L-Ala-D-Glu binding. REGION 158 159 UDP-MurNAc-L-Ala-D-Glu binding. REGION 414 417 Meso-diaminopimelate binding. MOTIF 414 417 Meso-diaminopimelate recognition motif. BINDING 27 27 UDP-MurNAc-L-Ala-D-Glu; via carbonyl BINDING 29 29 UDP-MurNAc-L-Ala-D-Glu. BINDING 157 157 UDP-MurNAc-L-Ala-D-Glu. BINDING 185 185 UDP-MurNAc-L-Ala-D-Glu. BINDING 191 191 UDP-MurNAc-L-Ala-D-Glu. BINDING 193 193 UDP-MurNAc-L-Ala-D-Glu. BINDING 390 390 Meso-diaminopimelate. BINDING 465 465 Meso-diaminopimelate; via carbonyl BINDING 469 469 Meso-diaminopimelate. MOD_RES 225 225 N6-carboxylysine. |
Keyword | 3D-structure; ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Direct protein sequencing; Ligase; Nucleotide-binding; Peptidoglycan synthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 495 AA |
Protein Sequence | MADRNLRDLL APWVPDAPSR ALREMTLDSR VAAAGDLFVA VVGHQADGRR YIPQAIAQGV 60 AAIIAEAKDE ATDGEIREMH GVPVIYLSQL NERLSALAGR FYHEPSDNLR LVGVTGTNGK 120 TTTTQLLAQW SQLLGEISAV MGTVGNGLLG KVIPTENTTG SAVDVQHELA GLVDQGATFC 180 AMEVSSHGLV QHRVAALKFA ASVFTNLSRD HLDYHGDMEH YEAAKWLLYS EHHCGQAIIN 240 ADDEVGRRWL AKLPDAVAVS MEDHINPNCH GRWLKATEVN YHDSGATIRF SSSWGDGEIE 300 SHLMGAFNVS NLLLALATLL ALGYPLADLL KTAARLQPVC GRMEVFTAPG KPTVVVDYAH 360 TPDALEKALQ AARLHCAGKL WCVFGCGGDR DKGKRPLMGA IAEEFADVAV VTDDNPRTEE 420 PRAIINDILA GMLDAGHAKV MEGRAEAVTC AVMQAKENDV VLVAGKGHED YQIVGNQRLD 480 YSDRVTVARL LGVIA 495 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:HAMAP. GO:0047482; F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity; IDA:EcoliWiki. GO:0008765; F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity; IEA:HAMAP. GO:0007049; P:cell cycle; IEA:UniProtKB-KW. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP. GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. |
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