CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024233
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uncharacterized oxidoreductase MSMEG_2408/MSMEI_2347 
Protein Synonyms/Alias
  
Gene Name
 MSMEG_2408, MSMEI_2347 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
NCBI Taxa ID
 246196 
Lysine Modification
Position
Peptide
Type
References
262IASLETGKRLGPDPRpupylation[1]
Reference
 [1] Expansion of the mycobacterial "PUPylome".
 Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC.
 Mol Biosyst. 2010 Feb;6(2):376-85. [PMID: 20094657
Functional Description
  
Sequence Annotation
 NP_BIND 187 239 NADP (By similarity).
 ACT_SITE 49 49 Proton donor (By similarity).
 BINDING 107 107 Substrate (By similarity).
 CROSSLNK 262 262 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 Complete proteome; Isopeptide bond; Oxidoreductase; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 275 AA 
Protein Sequence
MSPRITLNDG NSIPQVGLGV WQTPAEDTER AVAAALQAGY RHIDTAAAYR NETETGRAIA 60
NSGVPREDIF LVTKLWNSDQ GYDATLAAFD ASVQRLGVDY LDLYLIHWPV PENNKFVDTF 120
KAFAHLRDQG RIRSIGVSNF EPEHLTTLIE ETGIVPAVNQ IELHPLLPQQ ELRDVHAKLG 180
IATEAWSPLG QGSLLADPVI TGIAEQHGKT PAQVLIRWHI QLGNIVIPKS VNPERIASNF 240
DVFDFELSGQ DITSIASLET GKRLGPDPRT FNFTG 275 
Gene Ontology
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.