Tag | Content |
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CPLM ID | CPLM-008153 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase epsilon |
Protein Synonyms/Alias | Protein-tyrosine phosphatase epsilon; R-PTP-epsilon |
Gene Name | Ptpre |
Gene Synonyms/Alias | Ptpe |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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662 | LDVFQAVKSLRLQRP | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Isoform 1 acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver (By similarity). Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. |
Sequence Annotation | DOMAIN 134 393 Tyrosine-protein phosphatase 1. DOMAIN 425 688 Tyrosine-protein phosphatase 2. REGION 334 340 Substrate binding (By similarity). ACT_SITE 334 334 Phosphocysteine intermediate (By ACT_SITE 629 629 Phosphocysteine intermediate (By BINDING 302 302 Substrate (By similarity). BINDING 378 378 Substrate (By similarity). MOD_RES 695 695 Phosphotyrosine. CARBOHYD 23 23 N-linked (GlcNAc...) (Potential). CARBOHYD 31 31 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative initiation; Alternative promoter usage; Cell membrane; Complete proteome; Cytoplasm; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 699 AA |
Protein Sequence | MEPFCPLLLA SFSLSLARAG QGNDTTPTES NWTSTTAGPP DPGASQPLLT WLLLPLLLLL 60 FLLAAYFFRF RKQRKAVVSS NDKKMPNGIL EEQEQQRVML LSRSPSGPKK FFPIPVEHLE 120 EEIRVRSADD CKRFREEFNS LPSGHIQGTF ELANKEENRE KNRYPNILPN DHCRVILSQV 180 DGIPCSDYIN ASYIDGYKEK NKFIAAQGPK QETVNDFWRM VWEQRSATIV MLTNLKERKE 240 EKCYQYWPDQ GCWTYGNIRV CVEDCVVLVD YTIRKFCIHP QLPDSCKAPR LVSQLHFTSW 300 PDFGVPFTPI GMLKFLKKVK TLNPSHAGPI VVHCSAGVGR TGTFIVIDAM MDMIHSEQKV 360 DVFEFVSRIR NQRPQMVQTD VQYTFIYQAL LEYYLYGDTE LDVSSLERHL QTLHSTATHF 420 DKIGLEEEFR KLTNVRIMKE NMRTGNLPAN MKKARVIQII PYDFNRVILS MKRGQEFTDY 480 INASFIDGYR QKDYFMATQG PLAHTVEDFW RMVWEWKSHT IVMLTEVQER EQDKCYQYWP 540 TEGSVTHGDI TIEIKSDTLS EAISVRDFLV TFKQPLARQE EQVRMVRQFH FHGWPEVGIP 600 AEGKGMIDLI AAVQKQQQQT GNHPITVHCS AGAGRTGTFI ALSNILERVK AEGLLDVFQA 660 VKSLRLQRPH MVQTLEQYEF CYKVVQDFID IFSDYANFK 699 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0045111; C:intermediate filament cytoskeleton; IEA:Compara. GO:0005634; C:nucleus; IEA:Compara. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0042803; F:protein homodimerization activity; IDA:MGI. GO:0004725; F:protein tyrosine phosphatase activity; IDA:MGI. GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:UniProtKB. GO:0033003; P:regulation of mast cell activation; IMP:UniProtKB. GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; IDA:MGI. |
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