UniProt Accession

 FRIL_HUMAN; P02792; B2R4B9; Q6IBT7; Q7Z2W1; Q86WI9; Q8WU07; Q96AU9; Q96CU0; Q9BTZ8 

Genbank Protein ID

 M11147; M10119; M12938; AY207005; CR456715; AK311773; BX571748; AC026803; BC002991; BC004245; BC008439; BC013928; BC016715; BC016346; BC016354; BC018990; BC021670; BC058820; BC062708; X03742; X03743; X03743 

Genbank Nucleotide ID

 AAA52439.1; AAA35831.1; AAA52440.1; AAO52739.1; CAG32996.1; BAG34716.1; CAE11873.1; AAH02991.2; AAH04245.1; AAH08439.1; AAH13928.1; AAH16715.1; AAH16346.1; AAH16354.1; AAH18990.1; AAH21670.1; AAH58820.1; AAH62708.1; CAA27382.1; CAA27383.1; CAA27384.1 

Protein Name

 Ferritin light chain 

Protein Synonyms/Alias

 Ferritin L subunit 

Gene Name

 FTL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
59	FRELAEEKREGYERL	ubiquitination	[1]
68	EGYERLLKMQNQRGG	ubiquitination	[1, 2]
83	RALFQDIKKPAEDEW	ubiquitination	[2]
84	ALFQDIKKPAEDEWG	ubiquitination	[1, 2]
92	PAEDEWGKTPDAMKA	ubiquitination	[1, 2]
98	GKTPDAMKAAMALEK	acetylation	[3]
98	GKTPDAMKAAMALEK	ubiquitination	[2]
105	KAAMALEKKLNQALL	ubiquitination	[2]
106	AAMALEKKLNQALLD	ubiquitination	[1, 2]
144	EEVKLIKKMGDHLTN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). 

Sequence Annotation

 DOMAIN 7 156 Ferritin-like diiron.
 REGION 54 61 Catalytic site for iron oxidation.
 METAL 54 54 Iron.
 METAL 57 57 Iron.
 METAL 58 58 Iron.
 METAL 61 61 Iron.
 METAL 64 64 Iron.
 MOD_RES 2 2 N-acetylserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disease mutation; Iron; Iron storage; Metal-binding; Neurodegeneration; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 175 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0008043; C:intracellular ferritin complex; IDA:UniProtKB.
 GO:0008199; F:ferric iron binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IDA:UniProtKB.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0006826; P:iron ion transport; IEA:InterPro.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 

Interpro

 IPR001519; Ferritin.
 IPR009040; Ferritin-like_diiron.
 IPR009078; Ferritin-like_SF.
 IPR012347; Ferritin-rel.
 IPR014034; Ferritin_CS.
 IPR008331; Ferritin_DPS_dom. 

Pfam

 PF00210; Ferritin 

SMART

  

PROSITE

 PS00540; FERRITIN_1
 PS00204; FERRITIN_2
 PS50905; FERRITIN_LIKE 

PRINTS