CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025801
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calpain 2, large [catalytic] subunit variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
703VRLETLFKIFKQLDPubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Hydrolase; Protease; Thiol protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 729 AA 
Protein Sequence
APGPGRAPAE RSAESPRPFS AQYGRRDRSM AGIAAKLAKD REAAEGLGSH ERAIKYLNQD 60
YEALRNECLE AGTLFQDPSF PAIPSALGFK ELGPYSSKTR GIEWKRPTEI CADPQFIIGG 120
ATRTDICQGA LGDCWLLAAI ASLTLNEEIL ARVVPLNQCF QENYAGIFHF QFWQYGEWVE 180
VVVDDRLPTK DGELLFVHSA EGSEFWSALL EKAYAKINGC YEALSGGATT EGFEDFTGGI 240
AEWYESKKPP PNLFKIIQKA LQKGSLLGCS IDITSAADSE AITFQKLVKG HAYSVTGAEE 300
VESNGSLQKL IRIRNPWGEV EWTGRWNDNC PSWNTIDPEE RERLTRRHED GEFWMSFSDF 360
LRHYSRLEIC NLTPDTLTSD TYKKWKLTKM DGNWRRGSTA GGCRNYPNTF WMNPQYLIKL 420
EEEDEDEEDG ESGCTFLVGL IQKHRRRQRK MGEDMHTIGF GIYEVPEELS GQTNIHLSKN 480
FFLTNRARER SDTFINLREV LNRFKLPPGE YILVPSTFEP NKDGDFCIRV FSEKKADYQA 540
VDDEIEANLE EFDISEDDID DGFRRLFAQL AGEDAEISAF ELQTILRRVL AKRQDIKSDG 600
FSIETCKIMV DMLDSDGSGK LGLKEFYILW TKIQKYQKIY REIDVDRSGT MNSYEMRKAL 660
EEAGFKMPCQ LHQVIVARFA DDQLIIDFDN FVRCLVRLET LFKIFKQLDP ENTGTIELDL 720
ISWLCFSVL 729 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR022684; Calpain_cysteine_protease.
 IPR022682; Calpain_domain_III.
 IPR022683; Calpain_III.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom.
 IPR000169; Pept_cys_AS.
 IPR001300; Peptidase_C2_calpain_cat. 
Pfam
 PF01067; Calpain_III
 PF00648; Peptidase_C2 
SMART
 SM00720; calpain_III
 SM00230; CysPc
 SM00054; EFh 
PROSITE
 PS50203; CALPAIN_CAT
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS00139; THIOL_PROTEASE_CYS 
PRINTS
 PR00704; CALPAIN.