CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012217
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Bystin 
Protein Synonyms/Alias
  
Gene Name
 BYSL 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
15RGVGGQEKHAPLADQacetylation[1]
78AEHGTGDKPAAPRERubiquitination[2]
139AIEMFMNKNPPARRTubiquitination[2]
154LADIIMEKLTEKQTEubiquitination[2, 3]
158IMEKLTEKQTEVETVubiquitination[2, 3]
242RIFASNLKERMAQRFubiquitination[2, 3, 4]
266RDDVAEYKRLNFHLYubiquitination[2, 3]
398ADLATDQKEALLELLubiquitination[2, 3, 5, 6]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos. 
Sequence Annotation
 MOD_RES 98 98 Phosphoserine.
 MOD_RES 167 167 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 437 AA 
Protein Sequence
MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV GPRLSRRILQ 60
QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD EDEEWPTLEK AATMTAAGHH 120
AEVVVDPEDE RAIEMFMNKN PPARRTLADI IMEKLTEKQT EVETVMSEVS GFPMPQLDPR 180
VLEVYRGVRE VLSKYRSGKL PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN 240
LKERMAQRFY NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC 300
TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY ALPYRVLDAL 360
VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA LLELLRLQPH PQLSPEIRRE 420
LQSAVPRDVE DVPITVE 437 
Gene Ontology
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0007565; P:female pregnancy; TAS:ProtInc.
 GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR007955; Bystin. 
Pfam
 PF05291; Bystin 
SMART
  
PROSITE
  
PRINTS