CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039863
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Elongator complex protein 1 
Protein Synonyms/Alias
  
Gene Name
 IKBKAP 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115PSADPTVKLGAVGGSubiquitination[1, 2]
125AVGGSGFKVCLRTPHubiquitination[2]
242ESPSLAIKPWKNSGGubiquitination[2]
322CLRDASFKTLQAGLSubiquitination[3]
357TVVPQDTKLVLQMPRubiquitination[2, 4]
386QIRKWLDKLMFKEAFubiquitination[2, 5]
466SRDPDGNKIDLVCDAubiquitination[2]
485MESINPHKYCLSILTubiquitination[2]
497ILTSHVKKTTPELEIubiquitination[2, 4]
576LPFLNTLKKMETNYQubiquitination[2]
589YQRFTIDKYLKRYEKubiquitination[2]
603KAIGHLSKCGPEYFPubiquitination[2]
619CLNLIKDKNLYNEALubiquitination[2]
706LGRTLAGKLVEQRKHubiquitination[2]
749EALRLVYKYNRLDIIubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 983 AA 
Protein Sequence
MWDPVTPYRL HVLCQGWHYL AYDWHWTTDR SVGDNSSDLS NVAVIDGNRV LVTVFRQTVV 60
PPPMCTYQLL FPHPVNQVTF LAHPQKSNDL AVLDASNQIS VYKCGDCPSA DPTVKLGAVG 120
GSGFKVCLRT PHLEKRYKIQ FENNEDQDVN PLKLGLLTWI EEDVFLAVSH SEFSPRSVIH 180
HLTAASSEMD EEHGQLNVSS SAAVDGVIIS LCCNSKTKSV VLQLADGQIF KYLWESPSLA 240
IKPWKNSGGF PVRFPYPCTQ TELAMIGEEE CVLGLTDRCR FFINDIEVAS NITSFAVYDE 300
FLLLTTHSHT CQCFCLRDAS FKTLQAGLSS NHVSHGEVLR KVERGSRIVT VVPQDTKLVL 360
QMPRGNLEVV HHRALVLAQI RKWLDKLMFK EAFECMRKLR INLNLIYDHN PKVFLGNVET 420
FIKQIDSVNH INLFFTELKE EDVTKTMYPA PVTSSVYLSR DPDGNKIDLV CDAMRAVMES 480
INPHKYCLSI LTSHVKKTTP ELEIVLQKVH ELQGNAPSDP DAVSAEEALK YLLHLVDVNE 540
LYDHSLGTYD FDLVLMVAEK SQKDPKEYLP FLNTLKKMET NYQRFTIDKY LKRYEKAIGH 600
LSKCGPEYFP ECLNLIKDKN LYNEALKLYS PSSQQYQDIS IAYGEHLMQE HMYEPAGLMF 660
ARCGAHEKAL SAFLTCGNWK QALCVAAQLN FTKDQLVGLG RTLAGKLVEQ RKHIDAAMVL 720
EECAQDYEEA VLLLLEGAAW EEALRLVYKY NRLDIIETNV KPSILEAQKN YMAFLDSQTA 780
TFSRHKKRLL VVRELKEQAQ QAGLDDEVPH GQESDLFSET SSVVSGSEMS GKYSHSNSRI 840
SARSSKNRRK AERKKHSLKE GSPLEDLALL EALSEVVQNT ENLKDEVYHI LKVLFLFEFD 900
EQGRELQKAF EDTLQLMERS LPEIWTLTYQ QNSATPVLGP NSTANSIMAS YQQQKTSVPV 960
LDAELFIPPK INRRTQWKLS LLD 983 
Gene Ontology
 GO:0030335; P:positive regulation of cell migration; IEA:Compara. 
Interpro
 IPR006849; IKI3. 
Pfam
 PF04762; IKI3 
SMART
  
PROSITE
  
PRINTS