UniProt Accession

 GNAO_RAT; P59215; P04900; P30033 

Genbank Protein ID

 M17526; M12671 

Genbank Nucleotide ID

 AAA40826.1; AAA41262.1 

Protein Name

 Guanine nucleotide-binding protein G(o) subunit alpha 

Protein Synonyms/Alias

  

Gene Name

 Gnao1 

Gene Synonyms/Alias

 Gna0; Gnao 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
24	KAIEKNLKEDGISAA	ubiquitination	[1]
32	EDGISAAKDVKLLLL	ubiquitination	[1]
35	ISAAKDVKLLLLGAG	ubiquitination	[1]
51	SGKSTIVKQMKIIHE	ubiquitination	[1]
54	STIVKQMKIIHEDGF	ubiquitination	[1]
98	LGVEYGDKERKADSK	ubiquitination	[1]
154	YQLNDSAKYYLDSLD	ubiquitination	[1]
181	DILRTRVKTTGIVET	ubiquitination	[1]
272	IILFLNKKDLFGEKI	ubiquitination	[1]
278	KKDLFGEKIKKSPLT	acetylation	[2]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (By similarity). 

Sequence Annotation

 NP_BIND 40 47 GTP (By similarity).
 NP_BIND 176 182 GTP (By similarity).
 NP_BIND 201 205 GTP (By similarity).
 NP_BIND 270 273 GTP (By similarity).
 METAL 47 47 Magnesium (By similarity).
 METAL 182 182 Magnesium (By similarity).
 BINDING 326 326 GTP; via amide nitrogen (By similarity).
 MOD_RES 346 346 Deamidated asparagine; in form Alpha-3.
 LIPID 2 2 N-myristoyl glycine.
 LIPID 3 3 S-palmitoyl cysteine.  

Keyword

 Alternative splicing; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Magnesium; Metal-binding; Myristate; Nucleotide-binding; Palmitate; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 354 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0019003; F:GDP binding; TAS:RGD.
 GO:0005525; F:GTP binding; IDA:RGD.
 GO:0003924; F:GTPase activity; IDA:RGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0007568; P:aging; IDA:RGD.
 GO:0007212; P:dopamine receptor signaling pathway; IBA:RefGenome.
 GO:0030900; P:forebrain development; IEP:RGD.
 GO:0007626; P:locomotory behavior; IEA:Compara.
 GO:0051926; P:negative regulation of calcium ion transport; IMP:RGD.
 GO:0031175; P:neuron projection development; IEP:RGD.
 GO:0043547; P:positive regulation of GTPase activity; IMP:RGD.
 GO:0008016; P:regulation of heart contraction; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEP:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
 GO:0043278; P:response to morphine; IEP:RGD. 

Interpro

 IPR001408; Gprotein_alpha_I.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00441; GPROTEINAI.