CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011145
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sister chromatid cohesion protein 2 
Protein Synonyms/Alias
  
Gene Name
 SCC2 
Gene Synonyms/Alias
 YDR180W; YD9395.14 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
133DSINIEKKSEIVSRPubiquitination[1]
897HSKEAYDKITHVLTIubiquitination[2]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Plays a structural role in chromatin. Involved in sister chromatid cohesion. Forms a complex with SCC4 required for the stable association of the cohesin complex with chromatin, which may act by hydrolyzing ATP from SMC1 and SMC3 heads. Also participates in DNA repair. 
Sequence Annotation
 REPEAT 695 732 HEAT 1.
 REPEAT 734 771 HEAT 2.
 REPEAT 806 843 HEAT 3.
 REPEAT 1132 1169 HEAT 4.
 REPEAT 1244 1281 HEAT 5.  
Keyword
 Cell cycle; Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1493 AA 
Protein Sequence
MSYPGKDKNI PGRIIEALED LPLSYLVPKD GLAALVNAPM RVSLPFDKTI FTSADDGRDV 60
NINVLGTANS TTSSIKNEAE KERLVFKRPS NFTSSANSVD YVPTNFLEGL SPLAQSVLST 120
HKGLNDSINI EKKSEIVSRP EAKHKLESVT SNAGNLSFND NSSNKKTKTS TGVTMTQANL 180
AEQYLNDLKN ILDIVGFDQN SAEIGNIEYW LQLPNKKFVL TTNCLTKLQM TIKNITDNPQ 240
LSNSIEITWL LRLLDVMVCN IKFSKSSLKM GLDDSMLRYI ALLSTIVLFN IFLLGKNDSN 300
LHRESYIMEP VNFLSDLIES LKILTIEYGS LKIEFDTFQE ALELLPKYIR NGPFLDDNVT 360
AKLVYIFSDL LMNNDIEATT NIQFQSFWDN VKRISSDILV SLFGSFDQQR GFIIEELLSH 420
IEKLPTKRIQ KKLRKVGNQN IYITDFTFTL MSMLENINCY SFCNQMKDIA PENIDLLKNE 480
YKKQEEFLFN IVEHINDTIL ERFFKNPSAL RYVIDNFVQD LLLLISSPQW PVTEKILSSL 540
LKRLLSVYSP SMQVSANIET ICLQLIGNIG STIFDIKCST RDHEDNNLIK MINYPETLPH 600
FFKSFEECIA YNETIKCRRS ATRFLWNLRL GTILILEEYT KDAKEQIITV DNELKKILEQ 660
IKDGGLGPEL ENREADFSTI KLDYFSILHA FELLNLYDPY LKLILSLLAK DKIKLRSTAI 720
KCLSMLASKD KVILSNPMVK ETIHRRLNDS SASVKDAILD LVSINSSYFE FYQQINNNYN 780
DDSIMVRKHV LRINEKMYDE TNDIVTKVYV IARILMKIED EEDNIIDMAR LILLNRWILK 840
VHEVLDQPEK LKEISSSVLL VMSRVAIMNE KCSQLFDLFL NFYLLNKEAH SKEAYDKITH 900
VLTILTDFLV QKIVELNSDD TNEKNSIVDK QNFLNLLAKF ADSTVSFLTK DHITALYPYM 960
VSDEKSDFHY YILQVFRCTF EKLANFKQKF LYDLETTLLS RLPKMNVREI DEAMPLIWSV 1020
ATHRHDTARV AKACSSCLSH LHPYINKANN EEAAIVVDGK LQRLIYLSTG FARFCFPKPS 1080
NDKIAFLQEG ETLYEHITKC LLVLSKDKIT HVIRRVAVKN LTKLCGNHPK LFNSRHVLHL 1140
LDKEFQSDQL DIKLVILESL YDLFLLEERK SVRNTGVNST LSSNSILKKK LLKTNRVEFA 1200
NDGVCSALAT RFLDNILQLC LLRDLKNSLV AIRLLKLILK FGYTNPSHSI PTVIALFAST 1260
SQYIRHVAYE LLEDLFEKYE TLVFSSLSRG VTKAIHYSIH TDEKYYYKHD HFLSLLEKLC 1320
GTGKKNGPKF FKVLKRIMQS YLDDITDLTS TNSSVQKSIF VLCTNISNIT FVSQYDLVSL 1380
LKTIDLTTDR LKEVIMDEIG DNVSSLSVSE EKLSGIILIQ LSLQDLGTYL LHLYGLRDDV 1440
LLLDIVEESE LKNKQLPAKK PDISKFSAQL ENIEQYSSNG KLLTYFRKHV KDT 1493 
Gene Ontology
 GO:0005729; C:2-micrometer circle DNA; IDA:SGD.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0000790; C:nuclear chromatin; IDA:SGD.
 GO:0032116; C:SMC loading complex; IPI:SGD.
 GO:0030543; P:2-micrometer plasmid partitioning; IC:SGD.
 GO:0006302; P:double-strand break repair; IMP:SGD.
 GO:0034087; P:establishment of mitotic sister chromatid cohesion; IMP:SGD.
 GO:0071169; P:establishment of protein localization to chromatin; IMP:SGD.
 GO:0070550; P:rDNA condensation; IMP:SGD.
 GO:0000972; P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; IMP:SGD.
 GO:0070058; P:tRNA gene clustering; IMP:SGD. 
Interpro
 IPR016024; ARM-type_fold.
 IPR026003; Cohesin_HEAT.
 IPR024986; Nipped-B_C. 
Pfam
 PF12765; Cohesin_HEAT
 PF12830; Nipped-B_C 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS