CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001614
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
 CAA10458.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; CAB60229.1; AAD54675.1; AAD54676.1; AAD54677.1; CAH71340.1; CAH71340.1; CAH71340.1; CAH71341.1; CAH71341.1; CAH71341.1; CAH71342.1; CAH71342.1; CAH71342.1; CAH71343.1; CAH71343.1; CAH71343.1; CAH71345.1; CAH71345.1; CAH71345.1; CAH71346.1; CAH71346.1; CAH71346.1; CAH71347.1; CAH71347.1; CAH71347.1; CAI22397.1; CAI22397.1; CAI22397.1; CAI22398.1; CAI22398.1; CAI22398.1; CAI22399.1; CAI22399.1; CAI22399.1; CAI22401.1; CAI22401.1; CAI22401.1; CAI22402.1; CAI22402.1; CAI22402.1; CAI22403.1; CAI22403.1; CAI22403.1; CAI22405.1; CAI22405.1; CAI22405.1; CAI22406.1; CAI22406.1; EAX06327.1; EAX06330.1; EAX06333.1; EAX06335.1; EAX06336.1; EAX06339.1; BAA34506.1; ABL59902.1 
Protein Name
 Latrophilin-2 
Protein Synonyms/Alias
 Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; Latrophilin homolog 1; Lectomedin-1 
Gene Name
 LPHN2 
Gene Synonyms/Alias
 KIAA0786; LEC1; LPHH1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
337DNESETGKNSIDYIYubiquitination[1]
692QLSANTVKQNSRNGLubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis (By similarity). 
Sequence Annotation
 DOMAIN 41 130 SUEL-type lectin.
 DOMAIN 135 394 Olfactomedin-like.
 DOMAIN 784 836 GPS.
 MOD_RES 1430 1430 Phosphoserine.
 CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).
 CARBOHYD 331 331 N-linked (GlcNAc...) (Potential).
 CARBOHYD 520 520 N-linked (GlcNAc...) (Potential).
 CARBOHYD 629 629 N-linked (GlcNAc...).
 CARBOHYD 731 731 N-linked (GlcNAc...) (Potential).
 CARBOHYD 744 744 N-linked (GlcNAc...) (Potential).
 CARBOHYD 787 787 N-linked (GlcNAc...) (Potential).
 CARBOHYD 792 792 N-linked (GlcNAc...) (Potential).
 CARBOHYD 813 813 N-linked (GlcNAc...) (Potential).
 DISULFID 136 318 By similarity.  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lectin; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1459 AA 
Protein Sequence
MVSSGCRMRS LWFIIVISFL PNTEGFSRAA LPFGLVRREL SCEGYSIDLR CPGSDVIMIE 60
SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR TQCIVVTGSD VFPDPCPGTY 120
KYLEVQYECV PYIFVCPGTL KAIVDSPCIY EAEQKAGAWC KDPLQAADKI YFMPWTPYRT 180
DTLIEYASLE DFQNSRQTTT YKLPNRVDGT GFVVYDGAVF FNKERTRNIV KFDLRTRIKS 240
GEAIINYANY HDTSPYRWGG KTDIDLAVDE NGLWVIYATE QNNGMIVISQ LNPYTLRFEA 300
TWETVYDKRA ASNAFMICGV LYVVRSVYQD NESETGKNSI DYIYNTRLNR GEYVDVPFPN 360
QYQYIAAVDY NPRDNQLYVW NNNFILRYSL EFGPPDPAQV PTTAVTITSS AELFKTIIST 420
TSTTSQKGPM STTVAGSQEG SKGTKPPPAV STTKIPPITN IFPLPERFCE ALDSKGIKWP 480
QTQRGMMVER PCPKGTRGTA SYLCMISTGT WNPKGPDLSN CTSHWVNQLA QKIRSGENAA 540
SLANELAKHT KGPVFAGDVS SSVRLMEQLV DILDAQLQEL KPSEKDSAGR SYNKAIVDTV 600
DNLLRPEALE SWKHMNSSEQ AHTATMLLDT LEEGAFVLAD NLLEPTRVSM PTENIVLEVA 660
VLSTEGQIQD FKFPLGIKGA GSSIQLSANT VKQNSRNGLA KLVFIIYRSL GQFLSTENAT 720
IKLGADFIGR NSTIAVNSHV ISVSINKESS RVYLTDPVLF TLPHIDPDNY FNANCSFWNY 780
SERTMMGYWS TQGCKLVDTN KTRTTCACSH LTNFAILMAH REIAYKDGVH ELLLTVITWV 840
GIVISLVCLA ICIFTFCFFR GLQSDRNTIH KNLCINLFIA EFIFLIGIDK TKYAIACPIF 900
AGLLHFFFLA AFAWMCLEGV QLYLMLVEVF ESEYSRKKYY YVAGYLFPAT VVGVSAAIDY 960
KSYGTEKACW LHVDNYFIWS FIGPVTFIIL LNIIFLVITL CKMVKHSNTL KPDSSRLENI 1020
KSWVLGAFAL LCLLGLTWSF GLLFINEETI VMAYLFTIFN AFQGVFIFIF HCALQKKVRK 1080
EYGKCFRHSY CCGGLPTESP HSSVKASTTR TSARYSSGTQ SRIRRMWNDT VRKQSESSFI 1140
SGDINSTSTL NQGHSLNNAR DTSAMDTLPL NGNFNNSYSL HKGDYNDSVQ VVDCGLSLND 1200
TAFEKMIISE LVHNNLRGSS KTHNLELTLP VKPVIGGSSS EDDAIVADAS SLMHSDNPGL 1260
ELHHKELEAP LIPQRTHSLL YQPQKKVKSE GTDSYVSQLT AEAEDHLQSP NRDSLYTSMP 1320
NLRDSPYPES SPDMEEDLSP SRRSENEDIY YKSMPNLGAG HQLQMCYQIS RGNSDGYIIP 1380
INKEGCIPEG DVREGQMQLV TSL 1403 
Gene Ontology
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0004930; F:G-protein coupled receptor activity; TAS:GDB.
 GO:0016524; F:latrotoxin receptor activity; NAS:UniProtKB.
 GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro. 
Interpro
 IPR022624; DUF3497.
 IPR017981; GPCR_2-like.
 IPR001879; GPCR_2_extracellular_dom.
 IPR003924; GPCR_2_latrophilin.
 IPR003334; GPCR_2_latrophilin_rcpt_C.
 IPR000832; GPCR_2_secretin-like.
 IPR017983; GPCR_2_secretin-like_CS.
 IPR000203; GPS_dom.
 IPR000922; Lectin_gal-bd_dom.
 IPR003112; Olfac-like. 
Pfam
 PF00002; 7tm_2
 PF12003; DUF3497
 PF02140; Gal_Lectin
 PF01825; GPS
 PF02793; HRM
 PF02354; Latrophilin
 PF02191; OLF 
SMART
 SM00303; GPS
 SM00008; HormR
 SM00284; OLF 
PROSITE
 PS00649; G_PROTEIN_RECEP_F2_1
 PS00650; G_PROTEIN_RECEP_F2_2
 PS50227; G_PROTEIN_RECEP_F2_3
 PS50261; G_PROTEIN_RECEP_F2_4
 PS50221; GPS
 PS51132; OLF
 PS50228; SUEL_LECTIN 
PRINTS
 PR00249; GPCRSECRETIN.
 PR01444; LATROPHILIN.