UniProt Accession

 PLCC_HUMAN; Q9NRZ7; D3DSL2; Q3ZCU2; Q6UWP6; Q6ZUC6; Q8N3Q7; Q9NRZ6 

Genbank Protein ID

 AF156774; AF156775; AB040138; AY358704; AP001054; CH471079; CH471079; CH471079; CH471079; BC011971; BC040603; BC063552; AK125804; AL832919 

Genbank Nucleotide ID

 AAF80336.1; AAF80337.1; BAB18943.1; AAQ89067.1; EAX09461.1; EAX09463.1; EAX09464.1; EAX09465.1; AAH11971.1; AAH40603.1; AAH63552.1; BAC86299.1; CAD38635.2 

Protein Name

 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma 

Protein Synonyms/Alias

 1-acylglycerol-3-phosphate O-acyltransferase 3; 1-AGP acyltransferase 3; 1-AGPAT 3; Lysophosphatidic acid acyltransferase gamma; LPAAT-gamma 

Gene Name

 AGPAT3 

Gene Synonyms/Alias

 LPAAT3; UNQ759/PRO1490 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
119	FGVLGSSKVLAKKEL	ubiquitination	[1, 2]
201	AKGLPVLKYHLLPRT	ubiquitination	[1, 2]
236	TLNFRGNKNPSLLGI	ubiquitination	[1, 2]
247	LLGILYGKKYEADMC	ubiquitination	[1, 2]
281	LHKLYQEKDALQEIY	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. 

Sequence Annotation

 MOTIF 96 101 HXXXXD motif.  

Keyword

 Acyltransferase; Alternative splicing; Complete proteome; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleus; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 376 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0003841; F:1-acylglycerol-3-phosphate O-acyltransferase activity; NAS:UniProtKB.
 GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006654; P:phosphatidic acid biosynthetic process; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; TAS:Reactome. 

Interpro

 IPR002123; Plipid/glycerol_acylTrfase. 

Pfam

 PF01553; Acyltransferase 

SMART

 SM00563; PlsC 

PROSITE

  

PRINTS