UniProt Accession

 CENPK_HUMAN; Q9BS16; Q9H4L0 

Genbank Protein ID

 AY033646; AF315941; AY009151; BC005400; BC008504 

Genbank Nucleotide ID

 AAK59382.1; AAL26880.1; AAG31004.1; AAH05400.1; AAH08504.1 

Protein Name

 Centromere protein K 

Protein Synonyms/Alias

 CENP-K; Interphase centromere complex protein 37; Protein AF-5alpha; p33 

Gene Name

 CENPK 

Gene Synonyms/Alias

 ICEN37; FKSG14 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
76	AELSQWQKKTPETIP	ubiquitination	[1]
77	ELSQWQKKTPETIPL	ubiquitination	[2]
111	LEMVLSTKESKNEKL	ubiquitination	[2]
114	VLSTKESKNEKLKED	ubiquitination	[2]
119	ESKNEKLKEDLEREQ	ubiquitination	[2]
149	LHSELKNKVETFSES	ubiquitination	[2]
163	SRIFNELKTKMLNIK	ubiquitination	[2]
165	IFNELKTKMLNIKEY	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore. 

Sequence Annotation

  

Keyword

 Centromere; Chromosomal rearrangement; Chromosome; Coiled coil; Complete proteome; Kinetochore; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 269 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0034080; P:CENP-A containing nucleosome assembly at centromere; TAS:Reactome.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR020993; Centromere_CenpK. 

Pfam

 PF11802; CENP-K 

SMART

  

PROSITE

  

PRINTS