UniProt Accession

 MLP3A_MOUSE; Q91VR7; A2AVS1; Q9DC74 

Genbank Protein ID

 AK003122; AL929588; BC010596 

Genbank Nucleotide ID

 BAB22582.1; CAM27184.1; AAH10596.1 

Protein Name

 Microtubule-associated proteins 1A/1B light chain 3A 

Protein Synonyms/Alias

 Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha 

Gene Name

 Map1lc3a 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
51	LPVLDKTKFLVPDHV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). 

Sequence Annotation

 MOD_RES 12 12 Phosphoserine; by PKA (By similarity).
 LIPID 120 120 Phosphatidylethanolamine amidated glycine  

Keyword

 Autophagy; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Lipoprotein; Membrane; Microtubule; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 121 AA 

Protein Sequence

Gene Ontology

 GO:0000421; C:autophagic vacuole membrane; IDA:MGI.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0005770; C:late endosome; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0008429; F:phosphatidylethanolamine binding; IEA:Compara.
 GO:0000045; P:autophagic vacuole assembly; ISS:UniProtKB.
 GO:0000422; P:mitochondrion degradation; IEA:Compara. 

Interpro

 IPR004241; Atg8_ubiquitin-like. 

Pfam

 PF02991; Atg8 

SMART

  

PROSITE

  

PRINTS