| Tag | Content |
|---|
| CPLM ID | CPLM-023209 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Zinc finger protein PLAGL1 |
Protein Synonyms/Alias | Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor suppressor ZAC |
Gene Name | PLAGL1 |
Gene Synonyms/Alias | LOT1; ZAC |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 319 | PLASLPLKADTKGFC | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. |
Sequence Annotation | ZN_FING 4 26 C2H2-type 1.
ZN_FING 32 56 C2H2-type 2.
ZN_FING 62 84 C2H2-type 3.
ZN_FING 91 113 C2H2-type 4.
ZN_FING 120 142 C2H2-type 5.
ZN_FING 156 178 C2H2-type 6.
ZN_FING 184 207 C2H2-type 7. |
Keyword | Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 463 AA |
Protein Sequence | MATFPCQLCG KTFLTLEKFT IHNYSHSRER PYKCVQPDCG KAFVSRYKLM RHMATHSPQK 60
SHQCAHCEKT FNRKDHLKNH LQTHDPNKMA FGCEECGKKY NTMLGYKRHL ALHAASSGDL 120
TCGVCALELG STEVLLDHLK AHAEEKPPSG TKEKKHQCDH CERCFYTRKD VRRHLVVHTG 180
CKDFLCQFCA QRFGRKDHLT RHTKKTHSQE LMKESLQTGD LLSTFHTISP SFQLKAAALP 240
PFPLGASAQN GLASSLPAEV HSLTLSPPEQ AAQPMQPLPE SLASLHPSVS PGSPPPPLPN 300
HKYNTTSTSY SPLASLPLKA DTKGFCNISL FEDLPLQEPQ SPQKLNPGFD LAKGNAGKVN 360
LPKELPADAV NLTIPASLDL SPLLGFWQLP PPATQNTFGN STLALGPGES LPHRLSCLGQ 420
QQQEPPLAMG TVSLGQLPLP PIPHVFSAGT GSAILPHFHH AFR 463 |
Gene Ontology | GO:0005634; C:nucleus; IBA:RefGenome. GO:0003677; F:DNA binding; IDA:MGI. GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IBA:RefGenome. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007050; P:cell cycle arrest; TAS:ProtInc. GO:0030154; P:cell differentiation; IBA:RefGenome. GO:0006917; P:induction of apoptosis; TAS:ProtInc. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |