UniProt Accession

 F5H4B1_HUMAN; F5H4B1 

Genbank Protein ID

 D87011; D87013 

Genbank Nucleotide ID

  

Protein Name

 Melanoma antigen preferentially-expressed in tumors 

Protein Synonyms/Alias

  

Gene Name

 PRAME 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
208	AMPMQDIKMILKMVQ	ubiquitination	[1, 2]
235	WKLPTLAKFSPYLGQ	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 493 AA 

Protein Sequence

Gene Ontology

 GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
 GO:0045596; P:negative regulation of cell differentiation; IEA:InterPro.
 GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:InterPro.
 GO:0008284; P:positive regulation of cell proliferation; IEA:InterPro. 

Interpro

 IPR026292; PRAME/Leu_rich_rep-con_p14.
 IPR026271; PRAME_family. 

Pfam

  

SMART

  

PROSITE

  

PRINTS