CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008735
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Integrin alpha-8 
Protein Synonyms/Alias
 Integrin alpha-8 heavy chain; Integrin alpha-8 light chain 
Gene Name
 ITGA8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
418AGKDQRGKVLIYNGNubiquitination[1]
573RVFPLVIKRQKSHQCubiquitination[1]
948GGESAVLKVRSRLWAubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. 
Sequence Annotation
 REPEAT 44 105 FG-GAP 1.
 REPEAT 122 183 FG-GAP 2.
 REPEAT 188 240 FG-GAP 3.
 REPEAT 253 310 FG-GAP 4.
 REPEAT 311 372 FG-GAP 5.
 REPEAT 373 431 FG-GAP 6.
 REPEAT 435 498 FG-GAP 7.
 MOTIF 455 457 Cell attachment site (Potential).
 CARBOHYD 81 81 N-linked (GlcNAc...) (Potential).
 CARBOHYD 122 122 N-linked (GlcNAc...) (Potential).
 CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
 CARBOHYD 239 239 N-linked (GlcNAc...) (Potential).
 CARBOHYD 302 302 N-linked (GlcNAc...) (Potential).
 CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
 CARBOHYD 504 504 N-linked (GlcNAc...) (Potential).
 CARBOHYD 601 601 N-linked (GlcNAc...) (Potential).
 CARBOHYD 605 605 N-linked (GlcNAc...) (Potential).
 CARBOHYD 719 719 N-linked (GlcNAc...) (Potential).
 CARBOHYD 737 737 N-linked (GlcNAc...) (Potential).
 CARBOHYD 753 753 N-linked (GlcNAc...) (Potential).
 CARBOHYD 780 780 N-linked (GlcNAc...) (Potential).
 CARBOHYD 896 896 N-linked (GlcNAc...) (Potential).
 CARBOHYD 923 923 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1005 1005 N-linked (GlcNAc...) (Potential).
 DISULFID 96 106 By similarity.
 DISULFID 150 171 By similarity.
 DISULFID 187 200 By similarity.
 DISULFID 507 518 By similarity.
 DISULFID 524 580 By similarity.
 DISULFID 641 647 By similarity.
 DISULFID 713 726 By similarity.
 DISULFID 867 924 Interchain (between heavy and light
 DISULFID 929 934 By similarity.  
Keyword
 Calcium; Cell adhesion; Cleavage on pair of basic residues; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Integrin; Membrane; Metal-binding; Neurogenesis; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1063 AA 
Protein Sequence
MSPGASRGPR GSQAPLIAPL CCAAAALGML LWSPACQAFN LDVEKLTVYS GPKGSYFGYA 60
VDFHIPDART ASVLVGAPKA NTSQPDIVEG GAVYYCPWPA EGSAQCRQIP FDTTNNRKIR 120
VNGTKEPIEF KSNQWFGATV KAHKGKVVAC APLYHWRTLK PTPEKDPVGT CYVAIQNFSA 180
YAEFSPCRNS NADPEGQGYC QAGFSLDFYK NGDLIVGGPG SFYWQGQVIT ASVADIIANY 240
SFKDILRKLA GEKQTEVAPA SYDDSYLGYS VAAGEFTGDS QQELVAGIPR GAQNFGYVSI 300
INSTDMTFIQ NFTGEQMASY FGYTVVVSDV NSDGLDDVLV GAPLFMEREF ESNPREVGQI 360
YLYLQVSSLL FRDPQILTGT ETFGRFGSAM AHLGDLNQDG YNDIAIGVPF AGKDQRGKVL 420
IYNGNKDGLN TKPSQVLQGV WASHAVPSGF GFTLRGDSDI DKNDYPDLIV GAFGTGKVAV 480
YRARPVVTVD AQLLLHPMII NLENKTCQVP DSMTSAACFS LRVCASVTGQ SIANTIVLMA 540
EVQLDSLKQK GAIKRTLFLD NHQAHRVFPL VIKRQKSHQC QDFIVYLRDE TEFRDKLSPI 600
NISLNYSLDE STFKEGLEVK PILNYYRENI VSEQAHILVD CGEDNLCVPD LKLSARPDKH 660
QVIIGDENHL MLIINARNEG EGAYEAELFV MIPEEADYVG IERNNKGFRP LSCEYKMENV 720
TRMVVCDLGN PMVSGTNYSL GLRFAVPRLE KTNMSINFDL QIRSSNKDNP DSNFVSLQIN 780
ITAVAQVEIR GVSHPPQIVL PIHNWEPEEE PHKEEEVGPL VEHIYELHNI GPSTISDTIL 840
EVGWPFSARD EFLLYIFHIQ TLGPLQCQPN PNINPQDIKP AASPEDTPEL SAFLRNSTIP 900
HLVRKRDVHV VEFHRQSPAK ILNCTNIECL QISCAVGRLE GGESAVLKVR SRLWAHTFLQ 960
RKNDPYALAS LVSFEVKKMP YTDQPAKLPE GSIVIKTSVI WATPNVSFSI PLWVIILAIL 1020
LGLLVLAILT LALWKCGFFD RARPPQEDMT DREQLTNDKT PEA 1063 
Gene Ontology
 GO:0034678; C:alpha8-beta1 integrin complex; TAS:BHF-UCL.
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0030030; P:cell projection organization; IEA:Compara.
 GO:0016337; P:cell-cell adhesion; NAS:UniProtKB.
 GO:0007160; P:cell-matrix adhesion; NAS:UniProtKB.
 GO:0045184; P:establishment of protein localization; IEA:Compara.
 GO:0030198; P:extracellular matrix organization; TAS:Reactome.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0007613; P:memory; IEA:Compara.
 GO:0001656; P:metanephros development; IEA:Compara.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:2000721; P:positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation; IEA:Compara.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0048745; P:smooth muscle tissue development; IEA:Compara. 
Interpro
 IPR013517; FG-GAP.
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha.
 IPR013649; Integrin_alpha-2.
 IPR018184; Integrin_alpha_C_CS. 
Pfam
 PF01839; FG-GAP
 PF00357; Integrin_alpha
 PF08441; Integrin_alpha2 
SMART
 SM00191; Int_alpha 
PROSITE
 PS51470; FG_GAP
 PS00242; INTEGRIN_ALPHA 
PRINTS
 PR01185; INTEGRINA.