CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015951
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interferon regulatory factor 2-binding protein 2 
Protein Synonyms/Alias
 IRF-2-binding protein 2; IRF-2BP2 
Gene Name
 IRF2BP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89KPPPLSAKDILLQQQubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle. 
Sequence Annotation
 ZN_FING 506 553 RING-type; degenerate.
 REGION 506 550 Cys-rich.
 MOTIF 354 361 Nuclear localization signal.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 175 175 Phosphoserine.
 MOD_RES 360 360 Phosphoserine.
 MOD_RES 455 455 Phosphoserine.
 MOD_RES 457 457 Phosphoserine.
 MOD_RES 460 460 Phosphoserine.  
Keyword
 Acetylation; Activator; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 587 AA 
Protein Sequence
MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE FVIETARQLK 60
RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG HGGPEAAPRA PQALERYPLA 120
AAAERPPRLG SDFGSSRPAA SLAQPPTPQP PPVNGILVPN GFSKLEEPPE LNRQSPNPRR 180
GHAVPPTLVP LMNGSATPLP TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS 240
VSSSAAVEHE QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN 300
RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV ARTARKRKPS 360
PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP PPPTASPHSN RTTPPEAAQN 420
GQSPMAALIL VADNAGGSHA SKDANQVHST TRRNSNSPPS PSSMNQRRLG PREVGGQGAG 480
NTGGLEPVHP ASLPDSSLAT SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ 540
QGASGEVYCP SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS 587 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR022750; Interferon_reg_fac2-bd1_2_Znf. 
Pfam
 PF11261; IRF-2BP1_2 
SMART
  
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS