UniProt Accession

 SNTB2_HUMAN; Q13425; Q9BY09 

Genbank Protein ID

 U40572; AF243385; BC048215 

Genbank Nucleotide ID

 AAC50449.1; AAK15149.1; AAH48215.1 

Protein Name

 Beta-2-syntrophin 

Protein Synonyms/Alias

 59 kDa dystrophin-associated protein A1 basic component 2; Syntrophin-3; SNT3; Syntrophin-like; SNTL 

Gene Name

 SNTB2 

Gene Synonyms/Alias

 D16S2531E; SNT2B2; SNTL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	AVWTRATKAGLVELL	ubiquitination	[1]
249	DRKIIPLKMCFAARN	ubiquitination	[2]
489	RYPFERLKMSADDGI	ubiquitination	[2, 3]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN. 

Sequence Annotation

 DOMAIN 115 198 PDZ.
 DOMAIN 163 300 PH 1.
 DOMAIN 325 437 PH 2.
 DOMAIN 484 540 SU.
 REGION 518 540 Calmodulin-binding (By similarity).
 MOD_RES 95 95 Phosphoserine.
 MOD_RES 110 110 Phosphoserine.
 MOD_RES 222 222 Phosphoserine.
 MOD_RES 233 233 Phosphoserine.
 MOD_RES 393 393 Phosphoserine.  

Keyword

 3D-structure; Actin-binding; Alternative splicing; Calcium; Calmodulin-binding; Cell junction; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Membrane; Microtubule; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 540 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016010; C:dystrophin-associated glycoprotein complex; TAS:ProtInc.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005543; F:phospholipid binding; IEA:InterPro. 

Interpro

 IPR001478; PDZ.
 IPR001849; Pleckstrin_homology.
 IPR015482; Syntrophin. 

Pfam

 PF00595; PDZ 

SMART

 SM00228; PDZ
 SM00233; PH 

PROSITE

 PS50106; PDZ
 PS50003; PH_DOMAIN 

PRINTS