CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004606
UniProt Accession
Genbank Protein ID
 X06358 
Genbank Nucleotide ID
Protein Name
 UDP-glucuronosyltransferase 2B17 
Protein Synonyms/Alias
 M-1; UDP-glucuronosyltransferase 2B5; UDPGT 2B5 
Gene Name
 Ugt2b17 
Gene Synonyms/Alias
 Ugt2b5 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
67AYYVLDPKKSPGLKFacetylation[1]
67AYYVLDPKKSPGLKFubiquitination[2]
73PKKSPGLKFETFPTSacetylation[1, 3]
73PKKSPGLKFETFPTSubiquitination[2]
83TFPTSVSKDNLENFFubiquitination[2]
135CKDVVSNKELMTKLQubiquitination[2]
140SNKELMTKLQESKFDubiquitination[2]
183SPGYQIEKSSGRFLLacetylation[1]
183SPGYQIEKSSGRFLLubiquitination[2]
339IPQKVLWKFDGKTPAubiquitination[2]
343VLWKFDGKTPATLGHubiquitination[2]
356GHNTRVYKWLPQNDLubiquitination[2]
423LNIRTMSKSDVLNALacetylation[4]
423LNIRTMSKSDVLNALubiquitination[2]
440VIENPFYKKNAIWLSubiquitination[2]
456IHHDQPMKPLDRAVFubiquitination[2]
Reference
 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
 UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 
Sequence Annotation
 CARBOHYD 316 316 N-linked (GlcNAc...) (Potential).
 CARBOHYD 483 483 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Endoplasmic reticulum; Glycoprotein; Glycosyltransferase; Membrane; Microsome; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 530 AA 
Protein Sequence
MPGKWISALL LLQISCCFRS VKCGKVLVWP MEFSHWMNIK IILDELVQRG HEVTVLRPSA 60
YYVLDPKKSP GLKFETFPTS VSKDNLENFF IKFVDVWTYE MPRDTCLSYS PLLQNMIDEF 120
SDYFLSLCKD VVSNKELMTK LQESKFDVLL SDPVASCGEL IAELLQIPFL YSIRFSPGYQ 180
IEKSSGRFLL PPSYVPVILS GLGGQMTFIE RIKNMICMLY FDFWFQMFND KKWDSFYSEY 240
LGRPTTLVET MGQAEMWLIR SNWDLEFPHP TLPNVDYVGG LHCKPAKPLP KDMEEFVQSS 300
GDHGVVVFSL GSMVSNMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGH NTRVYKWLPQ 360
NDLLGHPKTK AFVTHGGANG VYEAIYHGIP MIGIPLFGEQ HDNIAHMVAK GAAVALNIRT 420
MSKSDVLNAL EEVIENPFYK KNAIWLSTIH HDQPMKPLDR AVFWIEFVMR HKRAKHLRPL 480
GHNLTWYQYH SLDVIGFLLS CVATTIVLSV KCLLFIYRFF VKKENKMKNE 530 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0015020; F:glucuronosyltransferase activity; IEA:EC. 
Interpro
 IPR002213; UDP_glucos_trans. 
Pfam
 PF00201; UDPGT 
SMART
  
PROSITE
 PS00375; UDPGT 
PRINTS