CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028776
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Acetyl-coenzyme A synthetase, cytoplasmic 
Protein Synonyms/Alias
  
Gene Name
 Acss2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
67EFWGNIAKEFYWKTAubiquitination[1]
88QYNFDVTKGKIFTEWubiquitination[1]
227GEKLVNLKELADESLubiquitination[1]
236LADESLEKCREKGFPubiquitination[1]
271PSQSPPVKRPCPDVQubiquitination[1]
413RLWSIVDKYKVTKFYubiquitination[1]
418VDKYKVTKFYTAPTAubiquitination[1]
431TAIRMLMKFGDDPVTacetylation[2, 3, 4, 5, 6]
431TAIRMLMKFGDDPVTubiquitination[1]
439FGDDPVTKHSRASLQubiquitination[1]
555RFETTYFKKFPGYYVubiquitination[1]
651LKKQIREKIGPIATPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 714 AA 
Protein Sequence
MGLPEERRKS GSGSRAREET GAEGRVRGWS PPPEVRRSAH VPSLQRYREL HRRSVEEPRE 60
FWGNIAKEFY WKTACPGPFL QYNFDVTKGK IFTEWMKGAT TNICYNVLDR NVHEKKLGDK 120
VAFYWEGNEP GETTKITYRE LLVQVCQFSN VLRKQGIQKG DRVAIYMPMI LELVVAMLAC 180
ARLGALHSIV FAGFSAESLC ERILDSSCCL LITTDAFYRG EKLVNLKELA DESLEKCREK 240
GFPVRCCIVV KHLGRAELGM NDSPSQSPPV KRPCPDVQGK LREKSKCIRP QICWNEGVDL 300
WWHELMQQAG DECEPEWCDA EDPLFILYTS GSTGKPKGVV HTIGGYMLYV ATTFKYVFDF 360
HPEDVFWCTA DIGWITGHSY VTYGPLANGA TSVLFEGIPT YPDEGRLWSI VDKYKVTKFY 420
TAPTAIRMLM KFGDDPVTKH SRASLQVLGT VGEPINPEAW LWYHRVVGSQ RCPIVDTFWQ 480
TETGGHMLTP LPGATPMKPG SASFPFFGVA PAILNESGEE LEGEAEGYLV FKQPWPGIMR 540
TVYGNHTRFE TTYFKKFPGY YVTGDGCRRD QDGYYWITGR IDDMLNVSGH LLSTAEVESA 600
LVEHEAVAEA AVVGHPHPVK GECLYCFVTL CDGHTFSPTL TEELKKQIRE KIGPIATPDY 660
IQNAPGLPKT RSGKIMRRVL RKIAQNDHDL GDTSTVADPS VINHLFSHRC LTTQ 714 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0003987; F:acetate-CoA ligase activity; IDA:MGI.
 GO:0006085; P:acetyl-CoA biosynthetic process; IDA:MGI. 
Interpro
 IPR024597; Acyl-CoA_synth_DUF3448.
 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR025110; DUF4009. 
Pfam
 PF00501; AMP-binding
 PF11930; DUF3448
 PF13193; DUF4009 
SMART
  
PROSITE
 PS00455; AMP_BINDING 
PRINTS