| Tag | Content |
|---|
| CPLM ID | CPLM-006579 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pre-mRNA-splicing factor SNU114 |
Protein Synonyms/Alias | 114 kDa U5 small nuclear ribonucleoprotein component; Growth inhibitory protein 10 |
Gene Name | SNU114 |
Gene Synonyms/Alias | GIN10; YKL173W; YKL637 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 356 | WGSVYYHKGNFRTKP | methylation | [1] | | 935 | CQLYFWHKIWRKVPG | methylation | [1] |
|
Reference | [1] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications. Pang CN, Gasteiger E, Wilkins MR. BMC Genomics. 2010 Feb 5;11:92. [ PMID: 20137074] |
Functional Description | Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP. |
Sequence Annotation | NP_BIND 140 147 GTP (By similarity).
NP_BIND 214 218 GTP (By similarity).
NP_BIND 268 271 GTP (By similarity).
MOD_RES 85 85 Phosphoserine.
MOD_RES 88 88 Phosphothreonine. |
Keyword | Complete proteome; GTP-binding; mRNA processing; mRNA splicing; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1008 AA |
Protein Sequence | MEGDDLFDEF GNLIGVDPFD SDEEESVLDE QEQYQTNTFE GSGNNNEIES RQLTSLGSKK 60
ELGISLEHPY GKEVEVLMET KNTQSPQTPL VEPVTERTKL QEHTIFTQLK KNIPKTRYNR 120
DYMLSMANIP ERIINVGVIG PLHSGKTSLM DLLVIDSHKR IPDMSKNVEL GWKPLRYLDN 180
LKQEIDRGLS IKLNGSTLLC TDLESKSRMI NFLDAPGHVN FMDETAVALA ASDLVLIVID 240
VVEGVTFVVE QLIKQSIKNN VAMCFVINKL DRLILDLKLP PMDAYLKLNH IIANINSFTK 300
GNVFSPIDNN IIFASTKLGF TFTIKEFVSY YYAHSIPSSK IDDFTTRLWG SVYYHKGNFR 360
TKPFENVEKY PTFVEFILIP LYKIFSYALS MEKDKLKNLL RSNFRVNLSQ EALQYDPQPF 420
LKHVLQLIFR QQTGLVDAIT RCYQPFELFD NKTAHLSIPG KSTPEGTLWA HVLKTVDYGG 480
AEWSLVRIYS GLLKRGDTVR ILDTSQSESR QKRQLHDISK TETSNEDEDE DDETPSCEVE 540
EIGLLGGRYV YPVHEAHKGQ IVLIKGISSA YIKSATLYSV KSKEDMKQLK FFKPLDYITE 600
AVFKIVLQPL LPRELPKLLD ALNKISKYYP GVIIKVEESG EHVILGNGEL YMDCLLYDLR 660
ASYAKIEIKI SDPLTVFSES CSNESFASIP VSNSISRLGE ENLPGLSISV AAEPMDSKMI 720
QDLSRNTLGK GQNCLDIDGI MDNPRKLSKI LRTEYGWDSL ASRNVWSFYN GNVLINDTLP 780
DEISPELLSK YKEQIIQGFY WAVKEGPLAE EPIYGVQYKL LSISVPSDVN IDVMKSQIIP 840
LMKKACYVGL LTAIPILLEP IYEVDITVHA PLLPIVEELM KKRRGSRIYK TIKVAGTPLL 900
EVRGQVPVIE SAGFETDLRL STNGLGMCQL YFWHKIWRKV PGDVLDKDAF IPKLKPAPIN 960
SLSRDFVMKT RRRKGISTGG FMSNDGPTLE KYISAELYAQ LRENGLVP 1008 |
Gene Ontology | GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD. GO:0005682; C:U5 snRNP; IDA:SGD. GO:0005525; F:GTP binding; ISS:SGD. GO:0003924; F:GTPase activity; IMP:SGD. GO:0030623; F:U5 snRNA binding; IDA:SGD. GO:0000244; P:assembly of spliceosomal tri-snRNP; IMP:SGD. GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IGI:SGD. GO:0000388; P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11); IMP:SGD. |
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