CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033344
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Myotubularin-related protein 2 
Protein Synonyms/Alias
  
Gene Name
 MTMR2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84YGLETVCKDIRNLRFubiquitination[1]
184NIPDEELKRVASFRSubiquitination[2]
526EPIHNRYKELLAKRAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MEEPPLLPGE NIKDMAKDVT YICPFTGAVR GTLTVTNYRL YFKSMERDPP FVLDASLGVI 60
NRVEKIGGAS SRGENSYGLE TVCKDIRNLR FAHKPEGRTR RSIFENLMKY AFPVSNNLPL 120
FAFEYKEVFP ENGWKLYDPL LEYRRQGIPN ESWRITKINE RYELCDTYPA LLVVPANIPD 180
EELKRVASFR SRGRIPVLSW IHPESQATIT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ 240
SHKIFIFDAR PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP 300
NIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD RTAQLTSLAM 360
LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA DADRSPVFLQ FIDCVWQMTR 420
QFPTAFEFNE YFLITILDHL YSCLFGTFLC NSEQQRGKEN LPKRTVSLWS YINSQLEDFT 480
NPLYGSYSNH VLYPVASMRH LELWVGYYIR WNPRMKPQEP IHNRYKELLA KRAELQKKVE 540
ELQREISNRS TSSSERA 557 
Gene Ontology
 GO:0030424; C:axon; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0097060; C:synaptic membrane; IEA:Compara.
 GO:0008021; C:synaptic vesicle; IEA:Compara.
 GO:0005774; C:vacuolar membrane; IEA:Compara.
 GO:0052866; F:phosphatidylinositol phosphate phosphatase activity; IEA:Compara.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0097062; P:dendritic spine maintenance; IEA:Compara.
 GO:0046855; P:inositol phosphate dephosphorylation; IEA:Compara.
 GO:0032288; P:myelin assembly; IEA:Compara.
 GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential; IEA:Compara.
 GO:0031642; P:negative regulation of myelination; IEA:Compara.
 GO:2000645; P:negative regulation of receptor catabolic process; IEA:Compara.
 GO:0002091; P:negative regulation of receptor internalization; IEA:Compara.
 GO:0048666; P:neuron development; IEA:Compara.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
 GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:Compara.
 GO:2000643; P:positive regulation of early endosome to late endosome transport; IEA:Compara.
 GO:0051262; P:protein tetramerization; IEA:Compara. 
Interpro
 IPR004182; GRAM.
 IPR010569; Myotub-related.
 IPR017906; Myotubularin_phosphatase_dom.
 IPR011993; PH_like_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF02893; GRAM
 PF06602; Myotub-related
 PF00102; Y_phosphatase 
SMART
 SM00568; GRAM 
PROSITE
 PS51339; PPASE_MYOTUBULARIN
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2 
PRINTS