UniProt Accession

 LDH_GEOKA; Q5L2S0 

Genbank Protein ID

 BA000043 

Genbank Nucleotide ID

 BAD74760.1 

Protein Name

 L-lactate dehydrogenase 

Protein Synonyms/Alias

 L-LDH 

Gene Name

 ldh 

Gene Synonyms/Alias

 GK0475 

Created Date

 July 27, 2013 

Organism

 Geobacillus kaustophilus (strain HTA426) 

NCBI Taxa ID

 235909 

Lysine Modification

Position	Peptide	Type	References
87	ICAGANQKPGETRLD	acetylation	[1]
210	SKGEEAQKELERIFV	acetylation	[1]
230	AYQIIEKKGATYYGI	acetylation	[1]

Reference

 [1] Proteomic analysis of acetylation in thermophilic Geobacillus kaustophilus.
 Lee DW, Kim D, Lee YJ, Kim JA, Choi JY, Kang S, Pan JG.
 Proteomics. 2013 Aug;13(15):2278-82. [PMID: 23696451] 

Functional Description

  

Sequence Annotation

 NP_BIND 15 43 NAD (By similarity).
 ACT_SITE 179 179 Proton acceptor.
 BINDING 92 92 Substrate (By similarity).
 BINDING 124 124 NAD or substrate (By similarity).
 BINDING 155 155 Substrate (By similarity).
 BINDING 233 233 Substrate (By similarity).
 MOD_RES 224 224 Phosphotyrosine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004459; F:L-lactate dehydrogenase activity; IEA:HAMAP.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:HAMAP. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR011304; L-lactate_DH.
 IPR018177; L-lactate_DH_AS.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

 PS00064; L_LDH 

PRINTS

 PR00086; LLDHDRGNASE.