CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026174
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dihydrolipoyl dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 TTHA0233 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
66AETLHHLKVAEGFGLacetylation[1]
163WDSTRALKVEEGLPKacetylation[1]
284GLEKAGVKVDERGFIacetylation[1]
373GYKVKVGKFPLAASGacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 
Functional Description
  
Sequence Annotation
 NP_BIND 16 17 FAD.
 NP_BIND 36 37 FAD.
 NP_BIND 43 44 FAD.
 NP_BIND 114 115 FAD.
 NP_BIND 315 317 FAD.
 BINDING 12 12 FAD.
 BINDING 48 48 FAD.
 BINDING 53 53 FAD.
 BINDING 272 272 FAD.
 BINDING 309 309 FAD.
 BINDING 440 440 FAD; via carbonyl oxygen.  
Keyword
 3D-structure; Complete proteome; FAD; Flavoprotein; NAD; Nucleotide-binding; Oxidoreductase; Pyruvate; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 464 AA 
Protein Sequence
MTPMKTYDLI VIGTGPGGYH AAIRAAQLGL KVLAVEAGEV GGVCLNVGCI PTKALLHAAE 60
TLHHLKVAEG FGLKAKPELD LKKLGGWRDQ VVKKLTGGVG TLLKGNGVEL LRGFARLVGP 120
KEVEVGGERY GAKSLILATG SEPLELKGFP FGEDVWDSTR ALKVEEGLPK RLLVIGGGAV 180
GLELGQVYRR LGAEVTLIEY MPEILPQGDP ETAALLRRAL EKEGIRVRTK TKAVGYEKKK 240
DGLHVRLEPA EGGEGEEVVV DKVLVAVGRK PRTEGLGLEK AGVKVDERGF IRVNARMETS 300
VPGVYAIGDA ARPPLLAHKA MREGLIAAEN AAGKDSAFDY QVPSVVYTSP EWAGVGLTEE 360
EAKRAGYKVK VGKFPLAASG RALTLGGAEG MVKVVGDEET DLLLGVFIVG PQAGELIAEA 420
ALALEMGATL TDLALTVHPH PTLSESLMEA AEAFHKQAIH ILNR 464 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004148; F:dihydrolipoyl dehydrogenase activity; IEA:EC.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR006258; Lipoamide_DH.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom. 
Pfam
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.