CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044404
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TBC1 domain family member 8 
Protein Synonyms/Alias
  
Gene Name
 TBC1D8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
134SFVKGKVKALIAEETubiquitination[1]
290QEPSQITKRDLEARAubiquitination[1, 2, 3]
785LIRDSYEKFGDQSVEubiquitination[3]
814QGHEDTTKQNVLRVVubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1155 AA 
Protein Sequence
MWLKPEEVLL KNALKLWVTQ KSSCYFILQR RRGHGEGGGR LTGRLVGALD AVLDSNARVA 60
PFRILLQVPG SQVYSPIACG ELLNGSDVYW AIATGATLEE INQHWDWLEQ NLLHTLSVFD 120
NKDDIASFVK GKVKALIAEE TSSRLAEQEE EPEKFREALV KFEARFNFPE AEKLVTYYSC 180
CCWKGRVPRQ GWLYLSINHL CFYSFFLGKE LKLVVPWVDI QKLERTSNVF LTDTIRITTQ 240
NKERDFSMFL NLDEVFKVME QLADVTLRRL LDNEVFDLDP DLQEPSQITK RDLEARAQNE 300
FFRAFFRLPR KEKLHAVVDC SLWTPFSRCH TTGRMFASDS YICFASREDG CCKIILPLRE 360
VVSIEKMEDT SLLPHPIIVS IRSKVAFQFI ELRDRDSLVE ALLARLKQVH ANHPVHYDTS 420
ADDDMASLVF HSTSMCSDHR FGDLEMMSSQ NSEESEKEKS PLMHPDALVT AFQQSGSQSP 480
DSRMSREQIK ISLWNDHFVE YGRTVCMFRT EKIRKLVAMG IPESLRGRLW LLFSDAVTDL 540
ASHPGYYGNL VEESLGKCCL VTEEIERDLH RSLPEHPAFQ NETGIAALRR VLTAYAHRNP 600
KIGYCQSMNI LTSVLLLYTK EEEAFWLLVA VCERMLPDYF NHRVIGAQVD QSVFEELIKG 660
HLPELAEHMN DLSALASVSL SWFLTLFLSI MPLESAVNVV DCFFYDGIKA IFQLGLAVLE 720
ANAEDLCSSK DDGQALMILS RFLDHIKNED SPGPPVGSHH AFFSDDQEPY PVTDISDLIR 780
DSYEKFGDQS VEQIEHLRYK HRIRVLQGHE DTTKQNVLRV VIPEVSILPE DLEELYDLFK 840
REHMMSCYWE QPRPMASRHD PSRPYAEQYR IDARQFAHLF QLVSPWTCGA HTEILAERTF 900
RLLDDNMDQL IEFKAFVSCL DIMYNGEMNE KIKLLYRLHI PPALTENDRD SQSPLRNPLL 960
STSRPLVFGK PNGDAVDYQK QLKQMIKDLA KEKDKTEKEL PKMSQREFIQ FCKTLYSMFH 1020
EDPEENDLYQ AIATVTTLLL QIGEVGQRGS SSGSCSQECG EELRASAPSP EDSVFADTGK 1080
TPQDSQAFPE AAERDWTVSL EHILASLLTE QSLVNFFEKP LDMKSKLENA KINQYNLKTF 1140
EMSHQSQSEL KLSNL 1155 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR004182; GRAM.
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF02893; GRAM
 PF00566; RabGAP-TBC 
SMART
 SM00568; GRAM
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS