UniProt Accession

 MBNL2_MOUSE; Q8C181; Q3TPH4; Q5DTQ0; Q8BUD8 

Genbank Protein ID

 AK028797; AK085709; AK151913; AK151926; AK151957; AK159213; AK164372; AK167479; AK220470; BC075665 

Genbank Nucleotide ID

 BAC26125.1; BAC39515.1; BAE30793.1; BAE30803.1; BAE30829.1; BAE34902.1; BAE37762.1; BAE39560.1; BAD90497.1; AAH75665.1 

Protein Name

 Muscleblind-like protein 2 

Protein Synonyms/Alias

  

Gene Name

 Mbnl2 

Gene Synonyms/Alias

 Kiaa4072 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
178	QKLLRTDKLEVCREF	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity). 

Sequence Annotation

 ZN_FING 13 41 C3H1-type 1.
 ZN_FING 47 73 C3H1-type 2.
 ZN_FING 176 204 C3H1-type 3.
 ZN_FING 212 238 C3H1-type 4.  

Keyword

 Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; RNA-binding; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 373 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:MGI.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR000571; Znf_CCCH. 

Pfam

 PF00642; zf-CCCH 

SMART

 SM00356; ZnF_C3H1 

PROSITE

 PS50103; ZF_C3H1 

PRINTS