CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011356
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S proteasome regulatory subunit RPN7 
Protein Synonyms/Alias
  
Gene Name
 RPN7 
Gene Synonyms/Alias
 YPR108W; P8283.8 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
29PNYEVSEKAFLLTQSubiquitination[1]
190DQLYVKEKLEAVNSMacetylation[2]
405AQYHLLVKQGDGLLTacetylation[2]
416GLLTKLQKYGAAVRLacetylation[2]
416GLLTKLQKYGAAVRLubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). 
Sequence Annotation
 REPEAT 131 164 TPR.
 DOMAIN 221 392 PCI.
 MOD_RES 8 8 Phosphoserine.
 MOD_RES 77 77 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Phosphoprotein; Proteasome; Reference proteome; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 429 AA 
Protein Sequence
MVDVEEKSQE VEYVDPTVNR VPNYEVSEKA FLLTQSKVSI EQRKEAAEFV LAKIKEEEMA 60
PYYKYLCEEY LVNNGQSDLE HDEKSDSLNE WIKFDQELYN ELCKKNESKI KELNEKIQKL 120
EEDDEGELEQ AQAWINLGEY YAQIGDKDNA EKTLGKSLSK AISTGAKIDV MLTIARLGFF 180
YNDQLYVKEK LEAVNSMIEK GGDWERRNRY KTYYGIHCLA VRNFKEAAKL LVDSLATFTS 240
IELTSYESIA TYASVTGLFT LERTDLKSKV IDSPELLSLI STTAALQSIS SLTISLYASD 300
YASYFPYLLE TYANVLIPCK YLNRHADFFV REMRRKVYAQ LLESYKTLSL KSMASAFGVS 360
VAFLDNDLGK FIPNKQLNCV IDRVNGIVET NRPDNKNAQY HLLVKQGDGL LTKLQKYGAA 420
VRLTGSDRV 429 
Gene Ontology
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0008541; C:proteasome regulatory particle, lid subcomplex; IDA:SGD.
 GO:0005198; F:structural molecule activity; IMP:SGD.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:SGD. 
Interpro
 IPR019585; 26S_proteasome_reg_su-Rpn7.
 IPR000717; PCI_dom.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01399; PCI
 PF10602; RPN7 
SMART
 SM00088; PINT 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS