CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024222
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-6-phosphate 1-dehydrogenase 
Protein Synonyms/Alias
 G6PD 
Gene Name
 zwf 
Gene Synonyms/Alias
 MSMEG_0314; MSMEI_0307 
Created Date
 July 27, 2013 
Organism
 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
NCBI Taxa ID
 246196 
Lysine Modification
Position
Peptide
Type
References
51TRIIGVAKAGLDDAGpupylation[1]
Reference
 [1] Expansion of the mycobacterial "PUPylome".
 Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC.
 Mol Biosyst. 2010 Feb;6(2):376-85. [PMID: 20094657] 
Functional Description
  
Sequence Annotation
 ACT_SITE 246 246 Proton acceptor (By similarity).
 BINDING 19 19 NADP (By similarity).
 BINDING 184 184 Substrate (By similarity).
 BINDING 188 188 Substrate (By similarity).
 CROSSLNK 51 51 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 Carbohydrate metabolism; Complete proteome; Glucose metabolism; Isopeptide bond; NADP; Oxidoreductase; Reference proteome; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 495 AA 
Protein Sequence
MNRTPSPVDP CDFVIFGGTG DLAARKLLPA LYLRDRDGQL AGATRIIGVA KAGLDDAGYR 60
NTVRAGLARH VEPDLLDSDV VDRFLSRLRF VSVDLTEPSD YAAVGDVLTS PDGGSGHDIR 120
VFYLACAPAL FGPICGALGA QGLVTESSRV VLEKPIGRDL ASAQQINEAV GAVFAEHQIF 180
RIDHYLGKES VQQLLVTRFG NTWLEPLWNS SRIDHVQITA AESLGVGARG DYYDQSGALR 240
DMLQNHLLQV LCLVAMEPPT HVNRESVRDE KRKVLEALEP LTAEQTQRDT VTGQYGPGLV 300
GDEVVGSYRE EVADPHSRTE TFVAVKAHIR NWRWAGVPFY LRTGKRMSQR FSEIVVQFKP 360
VPLPMFPGIE GTSEPNRLII SLQPDEAIRL EMTAKEPGSG GRLRPVSLAL NYTEAFPERS 420
PDAYERLLMD VVRGDPTLFM RRDEVEAAWA WAEPILRHWQ DADRVPRTYP AGTDGPVDAA 480
TLIERDGRRW HGGAA 495 
Gene Ontology
 GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:EC.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001282; G6P_DH.
 IPR019796; G6P_DH_AS.
 IPR022675; G6P_DH_C.
 IPR022674; G6P_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02781; G6PD_C
 PF00479; G6PD_N 
SMART
  
PROSITE
 PS00069; G6P_DEHYDROGENASE 
PRINTS
 PR00079; G6PDHDRGNASE.