| Tag | Content |
|---|
| CPLM ID | CPLM-022473 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Spliceosome-associated protein CWC15 homolog |
Protein Synonyms/Alias | |
Gene Name | CWC15 |
Gene Synonyms/Alias | C11orf5; AD-002; HSPC148 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 18 | PARGGRGKGEGDLSQ | acetylation | [1] |
|
Reference | [1] Integrated proteomic analysis of post-translational modifications by serial enrichment. Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA. Nat Methods. 2013 Jul;10(7):634-7. [ PMID: 23749302] |
Functional Description | Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. |
Sequence Annotation | MOD_RES 2 2 N-acetylthreonine.
MOD_RES 24 24 Phosphoserine (By similarity).
MOD_RES 110 110 Phosphothreonine.
MOD_RES 121 121 Phosphoserine. |
Keyword | Acetylation; Coiled coil; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 229 AA |
Protein Sequence | MTTAARPTFE PARGGRGKGE GDLSQLSKQY SSRDLPSHTK IKYRQTTQDA PEEVRNRDFR 60
RELEERERAA AREKNRDRPT REHTTSSSVS KKPRLDQIPA ANLDADDPLT DEEDEDFEEE 120
SDDDDTAALL AELEKIKKER AEEQARKEQE QKAEEERIRM ENILSGNPLL NLTGPSQPQA 180
NFKVKRRWDD DVVFKNCAKG VDDQKKDKRF VNDTLRSEFH KKFMEKYIK 229 |
Gene Ontology | GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB. GO:0003723; F:RNA binding; ISS:UniProtKB. GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB. |
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