| Tag | Content |
|---|
| CPLM ID | CPLM-023183 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | TBC1 domain family member 24 |
Protein Synonyms/Alias | |
Gene Name | TBC1D24 |
Gene Synonyms/Alias | KIAA1171 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 80 | VYSDIVGKIVGKHSS | ubiquitination | [1] | | 266 | PLESDSVKQDIRTFV | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. |
Sequence Annotation | DOMAIN 47 262 Rab-GAP TBC.
DOMAIN 368 554 TLD. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Epilepsy; GTPase activation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 559 AA |
Protein Sequence | MDSPGYNCFV DKDKMDAAIQ DLGPKELSCT ELQELKQLAR QGYWAQSHAL RGKVYQRLIR 60
DIPCRTVTPD ASVYSDIVGK IVGKHSSSCL PLPEFVDNTQ VPSYCLNARG EGAVRKILLC 120
LANQFPDISF CPALPAVVAL LLHYSIDEAE CFEKACRILA CNDPGRRLID QSFLAFESSC 180
MTFGDLVNKY CQAAHKLMVA VSEDVLQVYA DWQRWLFGEL PLCYFARVFD VFLVEGYKVL 240
YRVALAILKF FHKVRAGQPL ESDSVKQDIR TFVRDIAKTV SPEKLLEKAF AIRLFSRKEI 300
QLLQMANEKA LKQKGITVKQ KRQFVHLAVH AENFRSEIVS VREMRDIWSW VPERFALCQP 360
LLLFSSLQHG YSLARFYFQC EGHEPTLLLI KTTQKEVCGA YLSTDWSERN KFGGKLGFFG 420
TGECFVFRLQ PEVQRYEWVV IKHPELTKPP PLMAAEPTAP LSHSASSDPA DRLSPFLAAR 480
HFNLPSKTES MFMAGGSDCL IVGGGGGQAL YIDGDLNRGR TSHCDTFNNQ PLCSENFLIA 540
AVEAWGFQDP DTQ 553 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0005097; F:Rab GTPase activator activity; IEA:InterPro. GO:0031175; P:neuron projection development; IMP:UniProtKB. GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |