CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018852
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Amyloid beta A4 precursor protein-binding family B member 2 
Protein Synonyms/Alias
 Protein Fe65-like 1 
Gene Name
 APBB2 
Gene Synonyms/Alias
 FE65L; FE65L1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
159PSQPRRTKSFLNYYAubiquitination[1, 2, 3]
382VNPDPSLKEFEGATLubiquitination[2]
454IRQLSYCKNDIRDTVubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May modulate the internalization of beta-amyloid precursor protein. 
Sequence Annotation
 DOMAIN 290 322 WW.
 DOMAIN 413 578 PID 1.
 DOMAIN 584 736 PID 2.
 MOD_RES 123 123 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 758 AA 
Protein Sequence
MSEVLPADSG VDTLAVFMAS SGTTDVTNRN SPATPPNTLN LRSSHNELLN AEIKHTETKN 60
STPPKCRKKY ALTNIQAAMG LSDPAAQPLL GNGSANIKLV KNGENQLRKA AEQGQQDPNK 120
NLSPTAVINI TSEKLEGKEP HPQDSSSCEI LPSQPRRTKS FLNYYADLET SARELEQNRG 180
NHHGTAEEKS QPVQGQASTI IGNGDLLLQK PNRPQSSPED GQVATVSSSP ETKKDHPKTG 240
AKTDCALHRI QNLAPSDEES SWTTLSQDSA SPSSPDETDI WSDHSFQTDP DLPPGWKRVS 300
DIAGTYYWHI PTGTTQWERP VSIPADLQGS RKGSLSSVTP SPTPENEKQP WSDFAVLNGG 360
KINSDIWKDL HAATVNPDPS LKEFEGATLR YASLKLRNAP HPDDDDSCSI NSDPEAKCFA 420
VRSLGWVEMA EEDLAPGKSS VAVNNCIRQL SYCKNDIRDT VGIWGEGKDM YLILENDMLS 480
LVDPMDRSVL HSQPIVSIRV WGVGRDNGRD FAYVARDKDT RILKCHVFRC DTPAKAIATS 540
LHEICSKIMA ERKNAKALAC SSLQERANVN LDVPLQVDFP TPKTELVQKF HVQYLGMLPV 600
DKPVGMDILN SAIENLMTSS NKEDWLSVNM NVADATVTVI SEKNEEEVLV ECRVRFLSFM 660
GVGKDVHTFA FIMDTGNQRF ECHVFWCEPN AGNVSEAVQA ACMLRYQKCL VARPPSQKVR 720
PPPPPADSVT RRVTTNVKRG VLSLIDTLKQ KRPVTEMP 758 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0030426; C:growth cone; ISS:UniProtKB.
 GO:0030027; C:lamellipodium; ISS:UniProtKB.
 GO:0016020; C:membrane; NAS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0045202; C:synapse; ISS:UniProtKB.
 GO:0001540; F:beta-amyloid binding; ISS:UniProtKB.
 GO:0008134; F:transcription factor binding; ISS:UniProtKB.
 GO:0007411; P:axon guidance; IEA:Compara.
 GO:0007050; P:cell cycle arrest; ISS:UniProtKB.
 GO:0030198; P:extracellular matrix organization; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; ISS:UniProtKB. 
Interpro
 IPR011993; PH_like_dom.
 IPR006020; PTyr_interaction_dom.
 IPR001202; WW_dom. 
Pfam
 PF00640; PID
 PF00397; WW 
SMART
 SM00462; PTB
 SM00456; WW 
PROSITE
 PS01179; PID
 PS01159; WW_DOMAIN_1
 PS50020; WW_DOMAIN_2 
PRINTS