CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024392
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein TESPA1 
Protein Synonyms/Alias
 Thymocyte-expressed positive selection-associated protein 1 
Gene Name
 TESPA1 
Gene Synonyms/Alias
 KIAA0748; HSPC257 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13LSPTSWEKRRAWLRQubiquitination[1, 2]
193FTTPSQAKGIDFQLFubiquitination[2]
248VSKTPVQKFTPSHMFubiquitination[2]
289RLRKAISKMCLYTCPubiquitination[1, 2]
351PVPPAEGKKLPTSPYubiquitination[2]
352VPPAEGKKLPTSPYPubiquitination[2]
427NTETHPAKDETFWKRubiquitination[2]
445ARKSLFQKNLMGRKVubiquitination[2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. 
Sequence Annotation
 MOD_RES 311 311 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Signalosome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 521 AA 
Protein Sequence
MEASVLSPTS WEKRRAWLRQ SRNWQTQVLE EEAAAALQDV PDPEPSSLDD VFQEGNPINK 60
IEDWLQDCGY SEEGFSEEAG QFIYNGFCSH GTSFEDDLTL GAEATLLAAN GKLFSRSFLE 120
TARPCQLLDL GCSLASSSMT GGTNKTSSSI SEILDKVQED AEDVLFSLGF GQEDHKDTSR 180
IPARFFTTPS QAKGIDFQLF LKSQVRRIEM EDPCLMLASR FKQVQTLAVT ADAFFCLYSY 240
VSKTPVQKFT PSHMFWNCNH PTDVPSIRIL SREPEPQSPR DRLRKAISKM CLYTCPRDRP 300
PPPHNTPKRN SLDQVVLEVM DKVKEEKQFL QQDSDLGQFS QEDPVPPAEG KKLPTSPYPC 360
VFCCEEETQQ RMSTVLAPSQ TLDSNPKVPC CTHSLPIEDP QWSTDPAQIR RELCSLPATN 420
TETHPAKDET FWKRKSRARK SLFQKNLMGR KVKSLDLSIT QQKWKQSVDR PELRRSLSQQ 480
PQDTFDLEEV QSNSEEEQSQ SRWPSRPRHP HHHQTFAGKD S 521 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0008180; C:signalosome; IDA:UniProtKB.
 GO:0033089; P:positive regulation of T cell differentiation in thymus; ISS:UniProtKB.
 GO:0050862; P:positive regulation of T cell receptor signaling pathway; ISS:UniProtKB.
 GO:0010387; P:signalosome assembly; ISS:UniProtKB. 
Interpro
 IPR026647; TESPA1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS