CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007475
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 P2Y purinoceptor 2 
Protein Synonyms/Alias
 P2Y2; ATP receptor; P2U purinoceptor 1; P2U1; P2U receptor 1; Purinergic receptor 
Gene Name
 P2RY2 
Gene Synonyms/Alias
 P2RU1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
227LMARRLLKPAYGTSGubiquitination[1]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
 Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. 
Sequence Annotation
 CARBOHYD 9 9 N-linked (GlcNAc...) (Potential).
 CARBOHYD 13 13 N-linked (GlcNAc...) (Potential).
 DISULFID 106 183 By similarity.  
Keyword
 3D-structure; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL NAVALYIFLC 60
RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP FSTVLCKLVR FLFYTNLYCS 120
ILFLTCISVH RCLGVLRPLR SLRWGRARYA RRVAGAVWVL VLACQAPVLY FVTTSARGGR 180
VTCHDTSAPE LFSRFVAYSS VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK 240
RKSVRTIAVV LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC 300
LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE DVLGSSEDSR 360
RTESTPAGSE NTKDIRL 377 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IEA:InterPro.
 GO:0004872; F:receptor activity; TAS:ProtInc.
 GO:0006873; P:cellular ion homeostasis; TAS:ProtInc.
 GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; TAS:ProtInc.
 GO:0070257; P:positive regulation of mucus secretion; IEA:Compara. 
Interpro
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR000356; P2U_purnocptor.
 IPR002286; purinergic_P2Y_rcpt. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00237; GPCRRHODOPSN.
 PR00594; P2Y2PRNOCPTR.
 PR01157; P2YPURNOCPTR.