CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011108
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inner nuclear membrane protein SRC1 
Protein Synonyms/Alias
 Helix-extension-helix domain-containing protein 1 
Gene Name
 SRC1 
Gene Synonyms/Alias
 HEH1; YML034W; YML033W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
236NGSAILGKLSVKTPIacetylation[1]
295GHSTPLSKLKVSASFacetylation[1]
305VSASFADKLPQKEVPacetylation[1]
405PTEKDVEKCEARVQEubiquitination[2]
432NGSEFDVKQGSGKVGubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Plays a role in sister chromatid separation. 
Sequence Annotation
 MOD_RES 78 78 Phosphoserine.
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 181 181 Phosphoserine.
 MOD_RES 203 203 Phosphoserine.
 MOD_RES 204 204 Phosphoserine.
 MOD_RES 206 206 Phosphoserine.
 MOD_RES 301 301 Phosphoserine.
 MOD_RES 394 394 Phosphothreonine.
 MOD_RES 427 427 Phosphoserine.  
Keyword
 Complete proteome; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 834 AA 
Protein Sequence
MNSDLEYLED GFDPNSMKVA TLRRILVENN VDFPSNARKN ALVGLFDEKV KPQIPQLRKM 60
YLNVRPSDEG IVKMDRPSSS PSIASPRRSR RARREKSASP MAKQFKKNRI LDDVSNDDDD 120
DDDDDDDNDK KDDPLIVPSG TDTDEVDDEE DDVITSSSNK SDTNDFQQNS DTRKKRKDPD 180
SDDWSESNSK ENKIDNKHLN LLSSDSEIEQ DYQKAKKRKT SDLNQEHGNG SAILGKLSVK 240
TPIKNTNRKP VSMDNFNDSL TSSGTENDPF VPNIRHNPKE LGTANGTGHS TPLSKLKVSA 300
SFADKLPQKE VPSTILVPEV EQQEPSQSER TPSLFSSEGS GSESEAPLLP EITTPGPHQP 360
MGNTSNNVVE MIDTDSSNLV SDEDEVLVPT RIETPQLPTE KDVEKCEARV QELQEEVNEQ 420
LEHENGSEFD VKQGSGKVGN RHKFKRALKF LSKSLLALFL FCIFIVIPLL FGLWYREQRL 480
LIGYCGHEVP SHRVSGNSFE FIQKLDNLLQ DYRPKCIPCP PNGICYPYLK LKCKPDYKLA 540
PSRLDFLEII PAQGKCVKDD KKQQLVSEVV EKSLEFLRAK NAQISCGDGK DDIESGMTED 600
ALYQIFNEAR APWIRDDEFE DLWIQVIKDL TEEPEILWRQ LSPTDNNIGG NSNNIIKTND 660
VPRQKRHLPE KFISKTRNFR STSKKYIGMK CRFEREIYQT YKKFQRPIWL MFLLIVISKV 720
IEIKLKNYYR KKARIEELVT QTMEKLKFQK IKSMSDPKEN AYLSIVQLRD IFLSDIVDLK 780
YKNQLWSEVV KYLEHNNSNI KSNLTEIRGE IMKCWEWIGP MELNEPKDSA ENKI 834 
Gene Ontology
 GO:0005639; C:integral to nuclear inner membrane; IEA:InterPro.
 GO:0005635; C:nuclear envelope; IDA:SGD.
 GO:0043007; P:maintenance of rDNA; IMP:SGD.
 GO:0000070; P:mitotic sister chromatid segregation; IGI:SGD. 
Interpro
 IPR025856; HeH/LEM_domain.
 IPR018996; Inner-Nucl-membr_MAN1. 
Pfam
 PF12949; HeH
 PF09402; MSC 
SMART
  
PROSITE
  
PRINTS