CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014527
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S protease regulatory subunit 6B 
Protein Synonyms/Alias
 26S proteasome AAA-ATPase subunit RPT3; Proteasome 26S subunit ATPase 4; S6 ATPase; Tat-binding protein 7; TBP-7 
Gene Name
 Psmc4 
Gene Synonyms/Alias
 Tbp7 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
238VGSEFVQKYLGEGPRacetylation[1]
238VGSEFVQKYLGEGPRubiquitination[2]
330RPGRLDRKIEFPLPDacetylation[1]
397NRYIVLAKDFEKAYKacetylation[1]
401VLAKDFEKAYKTVIKacetylation[1]
404KDFEKAYKTVIKKDEacetylation[1]
408KAYKTVIKKDEQEHEacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. 
Sequence Annotation
 NP_BIND 206 213 ATP (Potential).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 397 397 N6-acetyllysine (By similarity).
 MOD_RES 401 401 N6-acetyllysine (By similarity).  
Keyword
 3D-structure; Acetylation; ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding; Nucleus; Phosphoprotein; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MEEIGILVEK IQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY 60
IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID 120
RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYADIGGM DIQKQEVREA 180
VELPLTHFEL YKQIGIDPPR GVLMYGPPGC GKTMLAKAVA HHTTAAFIRV VGSEFVQKYL 240
GEGPRMVRDV FRLAKENAPA IIFIDEIDAI ATKRFDAQTG ADREVQRILL ELLNQMDGFD 300
QNVNVKVIMA TNRADTLDPA LLRPGRLDRK IEFPLPDRRQ KRLIFSTITS KMNLSEEVDL 360
EDYVARPDKI SGADINSICQ ESGMLAVREN RYIVLAKDFE KAYKTVIKKD EQEHEFYK 418 
Gene Ontology
 GO:0031597; C:cytosolic proteasome complex; IDA:RGD.
 GO:0016234; C:inclusion body; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0022624; C:proteasome accessory complex; ISS:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; TAS:RGD.
 GO:0001824; P:blastocyst development; IEA:Compara.
 GO:0030163; P:protein catabolic process; IEA:InterPro. 
Interpro
 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00004; AAA 
SMART
 SM00382; AAA 
PROSITE
 PS00674; AAA 
PRINTS