UniProt Accession

 B2R4P9_HUMAN; B2R4P9 

Genbank Protein ID

 AK311905; CH471098; CH471099 

Genbank Nucleotide ID

 BAG34846.1; EAW69770.1; EAW89317.1 

Protein Name

 Histone H3 

Protein Synonyms/Alias

  

Gene Name

 H3F3B 

Gene Synonyms/Alias

 H3F3A; hCG_1984517; hCG_1989319 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
19	TGGKAPRKQLATKAA	ubiquitination	[1, 2]
24	PRKQLATKAARKSAP	ubiquitination	[1, 2]
37	APSTGGVKKPHRYRP	ubiquitination	[1]
57	REIRRYQKSTELLIR	ubiquitination	[1, 2]
80	REIAQDFKTDLRFQS	ubiquitination	[1, 2]
123	KRVTIMPKDIQLARR	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Chromosome; DNA-binding; Nucleosome core; Nucleus. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0009725; P:response to hormone stimulus; IEA:Compara. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000164; Histone_H3. 

Pfam

 PF00125; Histone 

SMART

 SM00428; H3 

PROSITE

 PS00322; HISTONE_H3_1
 PS00959; HISTONE_H3_2 

PRINTS

 PR00622; HISTONEH3.