CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007750
UniProt Accession
Genbank Protein ID
 X91249; AB038161; AJ289137; AJ289138; AJ289139; AJ289140; AJ289141; AJ289142; AJ289143; AJ289144; AJ289145; AJ289146; AJ289147; AJ289148; AJ289149; AJ289150; AJ289151; AF323658; AF323644; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323664; AF323658; AF323640; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323660; AF323663; AF323658; AF323642; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323662; AF323658; AF323643; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323658; AF323645; AF323646; AF323647; AF323648; AF323649; AF323650; AF323651; AF323652; AF323653; AF323654; AF323655; AF323656; AF323657; AF323661; AY048757; AP001746; BC029158; U34919 
Genbank Nucleotide ID
 CAA62631.1; BAB13728.2; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; CAC00730.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28836.1; AAK28842.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28833.1; AAK28838.1; AAK28841.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28835.1; AAK28840.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28837.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28834.1; AAK28839.1; AAL06598.1; BAA95530.1; AAH29158.2; AAC51098.1 
Protein Name
 ATP-binding cassette sub-family G member 1 
Protein Synonyms/Alias
 ATP-binding cassette transporter 8; White protein homolog 
Gene Name
 ABCG1 
Gene Synonyms/Alias
 ABC8; WHT1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55LLNGHLKKVDNNLTEubiquitination[1]
102KGYKTLLKGISGKFNubiquitination[1]
107LLKGISGKFNSGELVubiquitination[1]
140GYRETGMKGAVLINGubiquitination[1]
300GQCVYRGKVCNLVPYubiquitination[1]
376HRPSEEVKQTKRLKGubiquitination[1]
379SEEVKQTKRLKGLRKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. 
Sequence Annotation
 DOMAIN 77 317 ABC transporter.
 DOMAIN 415 673 ABC transmembrane type-2.
 NP_BIND 118 125 ATP (Potential).
 LIPID 30 30 S-palmitoyl cysteine.
 LIPID 154 154 S-palmitoyl cysteine.
 LIPID 315 315 S-palmitoyl cysteine.
 LIPID 394 394 S-palmitoyl cysteine.
 LIPID 406 406 S-palmitoyl cysteine.  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Lipid transport; Lipoprotein; Membrane; Mitochondrion; Nucleotide-binding; Palmitate; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 678 AA 
Protein Sequence
MACLMAAFSV GTAMNASSYS AEMTEPKSVC VSVDEVVSSN MEATETDLLN GHLKKVDNNL 60
TEAQRFSSLP RRAAVNIEFR DLSYSVPEGP WWRKKGYKTL LKGISGKFNS GELVAIMGPS 120
GAGKSTLMNI LAGYRETGMK GAVLINGLPR DLRCFRKVSC YIMQDDMLLP HLTVQEAMMV 180
SAHLKLQEKD EGRREMVKEI LTALGLLSCA NTRTGSLSGG QRKRLAIALE LVNNPPVMFF 240
DEPTSGLDSA SCFQVVSLMK GLAQGGRSII CTIHQPSAKL FELFDQLYVL SQGQCVYRGK 300
VCNLVPYLRD LGLNCPTYHN PADFVMEVAS GEYGDQNSRL VRAVREGMCD SDHKRDLGGD 360
AEVNPFLWHR PSEEVKQTKR LKGLRKDSSS MEGCHSFSAS CLTQFCILFK RTFLSIMRDS 420
VLTHLRITSH IGIGLLIGLL YLGIGNEAKK VLSNSGFLFF SMLFLMFAAL MPTVLTFPLE 480
MGVFLREHLN YWYSLKAYYL AKTMADVPFQ IMFPVAYCSI VYWMTSQPSD AVRFVLFAAL 540
GTMTSLVAQS LGLLIGAAST SLQVATFVGP VTAIPVLLFS GFFVSFDTIP TYLQWMSYIS 600
YVRYGFEGVI LSIYGLDRED LHCDIDETCH FQKSEAILRE LDVENAKLYL DFIVLGIFFI 660
SLRLIAYFVL RYKIRAER 678 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IC:UniProtKB.
 GO:0005739; C:mitochondrion; IDA:UniProtKB.
 GO:0055037; C:recycling endosome; ISS:BHF-UCL.
 GO:0043531; F:ADP binding; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; IDA:BHF-UCL.
 GO:0015485; F:cholesterol binding; IC:BHF-UCL.
 GO:0017127; F:cholesterol transporter activity; IDA:BHF-UCL.
 GO:0034437; F:glycoprotein transporter activity; IDA:BHF-UCL.
 GO:0005543; F:phospholipid binding; IC:BHF-UCL.
 GO:0005548; F:phospholipid transporter activity; IDA:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0034041; F:sterol-transporting ATPase activity; IDA:BHF-UCL.
 GO:0019534; F:toxin transporter activity; IDA:BHF-UCL.
 GO:0042987; P:amyloid precursor protein catabolic process; IDA:BHF-UCL.
 GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; IDA:BHF-UCL.
 GO:0008203; P:cholesterol metabolic process; IDA:BHF-UCL.
 GO:0009720; P:detection of hormone stimulus; NAS:UniProtKB.
 GO:0034436; P:glycoprotein transport; IDA:BHF-UCL.
 GO:0034375; P:high-density lipoprotein particle remodeling; ISS:BHF-UCL.
 GO:0032367; P:intracellular cholesterol transport; IMP:BHF-UCL.
 GO:0042157; P:lipoprotein metabolic process; TAS:Reactome.
 GO:0034374; P:low-density lipoprotein particle remodeling; ISS:BHF-UCL.
 GO:0010887; P:negative regulation of cholesterol storage; TAS:BHF-UCL.
 GO:0010745; P:negative regulation of macrophage derived foam cell differentiation; TAS:BHF-UCL.
 GO:0033700; P:phospholipid efflux; IMP:BHF-UCL.
 GO:0055091; P:phospholipid homeostasis; IMP:BHF-UCL.
 GO:0045542; P:positive regulation of cholesterol biosynthetic process; ISS:BHF-UCL.
 GO:0010875; P:positive regulation of cholesterol efflux; IEA:Compara.
 GO:0010872; P:regulation of cholesterol esterification; ISS:BHF-UCL.
 GO:0006355; P:regulation of transcription, DNA-dependent; ISS:BHF-UCL.
 GO:0055099; P:response to high density lipoprotein particle stimulus; IEA:Compara.
 GO:0033993; P:response to lipid; IDA:BHF-UCL.
 GO:0043691; P:reverse cholesterol transport; ISS:BHF-UCL. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR013525; ABC_2_trans.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR020064; ABC_transptr_G1-like.
 IPR027417; P-loop_NTPase.
 IPR005284; Pigment_permease. 
Pfam
 PF01061; ABC2_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS51012; ABC_TM2
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS